MLAB 1227: Coagulation

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Current Students

MLAB 1227: Coagulation

Dates: October 30- Dec. 10, 2023
Length of Course: 5 Weeks

Total Number of Hours: 48 Contact Hours

A course in coagulation theory, procedures, and practical applications. Includes quality control, quality assurance, safety and laboratory procedures which rely on commonly performed manual and/or semi-automated methods.

Course Objectives

By the end of this course the student should be able to:

Apply principles of safety, quality assurance and quality control in coagulation.
Evaluate specimen acceptability and dispose of them in the appropriate biohazard containers.
Compare and contrast coagulation processes under normal and abnormal human conditions.
Perform basic laboratory Coagulation analysis
Evaluate laboratory test results and correlate with patient conditions(s).
Demonstrate compliance with OSHA safety regulations for blood –borne pathogens.

Syllabus

Please print the MLAB 1227 Syllabus and bring it to class.

Textbook

Keohanne, Elaine M., Otto, Catherine N., and Walenga Jeanine M., Rodak’s Hematology: Clinical Principles and Applications, Sixth Edition, Elsevier, ISBN 978-0-323-53045-3

Assessment Dates

Quiz 1In class	Covers Chapters 10 (Platelets) and 35 (Normal Hemostasis)	Thursday, November 2, 2023
Quiz 2	Covers Chapter 42- section on the TEG & TEG video	Opens:Wednesday, November 8, 2023	Closes: Wednesday, November 15, 2023
Exam 1Remote	Covers: Chapters 10 (Platelets), 35( Normal Hemostasis), 41( Lab Evaluation of Hemostasis), and 42 (Hemostasis & Coagulation Instrumentation)Labs: Pre-analytical issues and coagulation automation	Opens: Friday, November 10, 2023 at 7 am	Closes: Saturday, November 11, 2023 at 8 pm
Quiz 3In class	Covers Chapter 37(Disorders of Platelets & Vasculature)	Thursday, November 9, 2023
Quiz 4In class	Covers Chapter 36(Disorders of Secondary Hemostasis)	Wednesday, November 15, 2023
Quiz 5In class	Covers Chapter 38(Thrombocytopenia & Thrombocytosis)	Thursday, November 16, 2023
Quiz 6	Covers Chapter 39 (Thrombotic Disorders and Lab Assessment)	Tuesday, November 21, 2023
Practical ExamOn Campus	Covers all labs, including Coagulation Automation and Lab Testing in Coagulation PPTs	EVC: Thursday, November 30, 20239:00-11:00 am Room 9209	RRC: Thursday, November 30, 20234:00-6:00 pm Room 3121.00
FinalOn Campus	Covers all lecture material	EVC: December 6, 202312- 2 p.mRoom 9317	RRC: December 6, 20233:30- 5:30 pmRoom 3121.00

Schedule

Admission tickets (ATs) and Pre-labs (PLs) are due by 8:30 a.m on the day the material is covered.

Week of 10/24/2023

Topic	N/A
Textbook	N/A
Laboratory	N/A
Assignment	Pre-Lab Assessment: Bleeding time. Found in Bb under the Assignments button in the Pre-Lab folder. Due 11/1/2023 Admission ticket: Overview of Hemostasis and Platelet Physiology. Found in Bb under Assignments button in the lecture admission tickets folder. Due 11/1/2023 Please review this tutorial of how the blood clots. ( 5 minutes)

11/1/2023

Lecture Topics	Overview of Hemostasis and Platelet Physiology \| Objectives \| Hemostasis Part 1 \| The Platelets \| Hemostasis Part 2 Pre-analytical Issues in Coagulation Testing \| Notes
Textbook	Ch. 10, pp. 136-151 Platelet Production, Structure, and Function Ch. 35, pp. 626-631 Normal Hemostasis Ch. 41, pp. 765-771, 780 Laboratory Evaluation of Hemostasis
Laboratory	Syllabus Review, Q & A Lab: Bleeding Time Lab: Thrombin Time
Assignment	Pre-Lab Assessment: Prothrombin Time (PT)/INR. Found in Bb under the Assignments button in the Pre-Lab folder. Due 11/2/2023 Preanalytical Case Studies in Bb under Assignments button, in the “Class activities” folder. Due by 11/8/2023 Helpful handouts for Secondary Hemostasis: Characteristics of Hemostatic Proteins \| Secondary Hemostasis – Y-shaped Pathways Additional handouts: Intrinsic and Extrinsic Coagulation Process \| Coagulation Overview – Vessel Damage

11/2/2023

Lecture Topics	Secondary Hemostasis: Coagulation Factors Intrinsic, Extrinsic, Common Pathways \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 35, pp. 631-638 Normal Hemostasis Ch. 41, pp. 775-777 (PT) Laboratory Evaluation of Hemostasis
Laboratory	Lab: Prothrombin Time & INR
Assignment	Pre-Lab Assessment: Hemostasis Testing; found in Bb under Assignments button in the lecture admission tickets folder. Due 11/8/2023 Admission ticket: Fibrinolysis and Physiologic Hemostasis; found in Bb under Assignments button in the lecture admission tickets folder. Due 11/8/2023 Watch the video “Warfarin” (15 minutes)

11/8/2023

Lecture Topics	Fibrinolysis \| Objectives \| Notes Physiologic Control of Hemostasis \| Objectives \| Notes
Textbook	Ch. 35, pp. 640-646 Normal Hemostasis Ch. 42, pp. 793-800, 803-806 (Platelet Function Testing) Hemostasis and Coagulation Instrumentation
Laboratory	Coagulation Automation \| Objectives \| Notes Laboratory Testing in Coagulation \| Objectives \| Notes
Assignment	Watch the Hemostasis, Coagulation, and Fibrinolysis video. (4 minutes) Pre-Lab Assessment: aPTT; found in Bb under the Assignments button in the Pre-Lab folder. Due 11/9/2023 Admission ticket: Primary Disorders; found in Bb under assignments button in the lecture admission tickets folder. Due 11/9/2023 Homework: TEG Video and Quiz; Review the video here and take the TEG quiz found in Blackboard, under the Exam button, in the “Exams/Quiz” folder in the “Quizzes” folder. Due 11/15/2023 Handout: Diagnostic Approach to Bleeding

11/9/2023

Lecture Topic	Coagulation Disorders: Primary Hemostasis \| Objectives \| Notes
Textbook	Ch. 37, pp. 675-691 Qualitative Disorders of Platelets and Vasculature Ch. 41, pp. 777-779 (PTT) Laboratory Evaluation of Hemostasis
Laboratory	Lab: PTT
Assignment	Pre-Lab Assessment: Fibrinogen; found in Bb under the Assignments button. Due 11/15/2023 Admission ticket: Secondary Disorders; found in Bb under assignments button. Due 11/15/2023 Homework: Inherited Platelet Defects; Due 11/16/2023 Navigate to the “Dropbox” in Bb, select the “Homework” folder, upload assignment. Watch the video “Heparin” (14 minutes) Watch the video “Heparin vs. Warfarin” (12 minutes.)

11/15/2023

Lecture Topic	Review Exam #1 as needed. Coagulation Disorders: Secondary Hemostasis \| Objectives \| Notes Part 1 \| Part 2
Textbook	Ch. 36, pp. 650-669 Hemorrhagic Disorders and Lab Assessment Ch. 39, pp. 734-736 (DIC) Laboratory Evaluation of Hemostasis
Laboratory	Lab: Fibrinogen
Assignment	TBA

11/16/2023

Topic	Thrombocytopenia & Thrombocytosis \| Objectives \| Notes
Textbook	Ch. 38, pp. 695-715 Thrombocytopenia and Thrombocytosis
Laboratory	Mixing Study Bring your copy of the PT and aPTT labs.
Assignment	Admission ticket: Thrombophilia; found in Bb under assignments button in the lecture admission tickets folder. Due 11/21/2023 Pre-Lab Assessment: D-dimer; found in Bb under the Assignments button in the Pre-Lab folder. Due 11/21/2023

11/21/2023

Topic	Thrombophilia \| Objectives \| Notes
Textbook	Ch. 39, pp. 720-741 Thrombotic Disorders and Lab Assessment Ch. 41, pp. 785 (D-dimer) Laboratory Evaluation of Hemostasis
Laboratory	Lab: D-dimer
Assignment	Thrombophilia Crossword. Navigate to the “Dropbox” in Bb, select the “Homework” folder, upload assignment. Due 11/26/2023

11/29/2023

Topic	TBA
Textbook
Laboratory
Assignment

11/30/2023

Topic
Textbook
Laboratory	Lab Practical
Assignment

12/6/2023

Topic	Course Final Exam
Textbook
Laboratory
Assignment

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MLAB 1227: Coagulation

Current Students

MLAB 1227: Coagulation

Course Objectives

Syllabus

Textbook

Assessment Dates

Schedule

Week of 10/24/2023

11/1/2023

11/2/2023

11/8/2023

11/9/2023

11/15/2023

11/16/2023

11/21/2023

11/29/2023

11/30/2023

12/6/2023

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