MLAB 1415: Hematology


MLAB 1415: Hematology

    • Dates: Aug. 21 – Oct. 29, 2023
    • Length of Course: 10 Weeks
  • Total Contact Hours: 128

The study of blood cells in normal and abnormal conditions. Instructions in the theory and practical application of hematology procedures, including quality control, quality assurance, safety, manual and/or automated methods as well as blood cell maturation sequences, and  normal and abnormal morphology with associated diseases.

By the end of this course the student should be able to:

  • Apply principles of safety, quality assurance, and quality control in hematology.
  • Determine suitability of hematology specimens and dispose of them in appropriate biohazard containers.
  • Compare and contrast hematology values under normal and abnormal conditions.
  • Evaluate normal and abnormal cell morphology with associated diseases.
  • Demonstrate an understanding of the cell components of human blood and characteristics, functions, and abnormalities and disease states of each.
  • Demonstrate proficiency in skills necessary to perform blood cell counts, and evaluations of blood elements within stated limits of accuracy.
  • Demonstrate compliance with OSHA safety regulations for blood-borne pathogens.
  • Identify principles and procedures of hematology tests to include sources of error and clinical significance of results.

Please print the MLAB 1415 course syllabus and bring it to class.

  1. Keohanne, Elaine M., Otto, Catherine N., and Walenga Jeanine M., Rodak’s Hematology: Clinical Principles and Applications, Sixth Edition, Elsevier, ISBN 978-0-323-53045-3
  2. Carr, Jacqueline H.,  Clinical Hematology Atlas, Sixth Edition, Elsevier, ISBN 978-0-323-711920
Exam 1On-Campus Covers:

  • Ch. 1 (Introduction to Hematology),
  • Ch. 3 (Cell Structure & Function),
  •  Ch. 4, (Hematopoiesis),  Ch. 5 (RBC Production/Destruction),
  • Ch. 6 (RBC Metabolism & Membrane Structure & Function),
  • Ch. 7 (Hemoglobin),
  • Ch. 9 (Leukocytes),
  • Ch. 10 (Platelets),
  • Ch. 14 (Bone Marrow Exam)

No labs.

EVC:Wednesday

Sept. 6, 2023

8:30-9:30 am

Room 9209

RRC:Wednesday

Sept. 6, 2023

3:30-4:30 pm

Room 3121.00

Exam 2On-Campus Covers Chapters  8, 16, 17, 18,19

  • Ch. 8 (Iron),
  • Ch. 16 (Anemias),
  • Ch. 17 (Disorders of Iron Kinetics & Heme Metabolism),
  • Ch.18 (Macrocytic Anemia),
  • Ch. 19 (Bone Marrow Failure)

No labs.

EVC:Wednesday

Sept. 20, 2023

8:30-10:00 am Room 9209

RRC:  Wednesday

Sept. 20, 2023

3:30-5:00 pm

Room 3121.00

Exam 3On- Campus Covers:

  • Ch. 20 (Introduction to Hemolytic Anemias),
  • Ch. 21 (Intrinsic Defects Affecting RBCs),
  • Ch. 22 (Extrinsic Defects Affecting RBCs- Nonimmune),
  • Ch. 23 (Extrinsic Defects Affecting RBCs- Immune)

No labs.

EVC:Wednesday

October 4, 2023

8:30-9:30am

Room 8310

RRC:Wednesday

October 4, 2023

3:30-4:30 pm

Room 3121.00

Exam 4:On-Campus Covers Chapters 24, 25, 26

  • Ch. 24 (Hemoglobinopathies)
  • Ch. 25 (Thalassemias)
  • Ch. 26 (Non-Malignant WBC Disorders)

No labs.

EVC:Wednesday

Oct. 11, 2023 8:30-9:30 am

Room 9209

RRC:Wednesday

Oct. 11, 2023 3:30-4:30 pm

Room 3121.00

Exam 5:Remote Covers:Introduction to Hematopoietic Neoplasms

  • Ch. 27 (Introduction to Hematologic Malignancies),
  • Ch. 31 (Acute Leukemias),
  • Ch. 32 (Myeloproliferative Disorders),
  • Ch. 33 (Myelodysplastic Syndromes),
  • Ch. 34 (Mature Lymphoid Neoplasms)
  • No labs.
Opens:Friday, Oct. 20, 2023 at 7:00 am Closes:Sunday, Oct. 22, 2023 at 7:00 pm
PRACTICAL EXAM:On-Campus Covers all labs EVC: WednesdayOct. 25, 20238:30-9:30 amRoom 9209 RRC: WednesdayOct. 25, 20233 :30-4:30  p.mRoom 3121.00
FINAL EXAM:On-Campus Covers all  course material. EVC:ThursdayOct. 26, 20238:30-10:30 amRoom 9317 RRC:ThursdayOct. 26, 20233:30- 5:30 pmRoom 3121.00

Admission tickets (ATs) and Pre-labs (PLs) are due by 8:30 a.m.

Week of 8/14/2023

Topic N/A
Textbook N/A
Laboratory N/A
Assignment
  • PL: Microhematocrit. Pre-lab is found in Bb under assignments tab. Due 8/23/23
  • PL: ESR. Pre-lab is found in Bb under assignments tab. Due 8/23/23

Wednesday 8/23/23

Laboratory Topic
Textbook
  • Ch. 1, pp. 1-7
    • Introduction to Hematology
  • Ch. 3, pp. 31-41
    • Cell Structure & Function
  • Hematology Atlas- Table 2-1, page 16
  • Ch. 4, pp. 43-59
    • Hematopoiesis
Lecture Topics
Assignment
  • PL: Blood Smear Preparation and Staining. Pre-lab is found in Bb under assignments tabDue 8/24/23
  • Read pages 2-7 in Hematology Atlas
  • Admission Ticket: Hematopoietic Organs and Bone Marrow. Found in Bb under assignments tab. Due 8/24/23
  • Cell Components and Function. Submit to Dropbox in Bb. Due 8/27/23

Thursday 8/24/23

Laboratory Topic
Textbook
    • Ch. 14, pp. 219-234
      • Bone Marrow Exam
Lecture Topics
Assignment

Wednesday 8/30/23

Laboratory Topic
  • Atlas Review: Basic cells
  • Hematek Stainer
  • Blood Smear Lab con’t
Textbook
  • Ch. 9, pp. 117-132
    • Leukocytes
  • Ch. 10, pp. 136-151
    • Platelets
Lecture Topics
Assignment

Thursday 8/31/23

Laboratory Topic
Textbook
  • Ch. 5, pp. 62-75
    • RBC Production/Destruction
  • Ch. 6, pp. 78-88
    • RBC Metabolism & Membrane Structure & Function
  • Ch. 7, pp. 91-102
    • Hemoglobin
Lecture Topics
Assignment
  • Admission Ticket: Anemia. Found in Bb under assignments tab. Due 9/6/23
  • PL: Electrical Impedance & Colorimetric Measurements: Pre-lab is found in Bb under assignments tab. Due 9/6/23
  • Hemoglobin Assignment. Due 9/3/23
  • RBC Metabolic Pathways Assignment: Submit to Dropbox: Due 9/3/2023

Wednesday 9/6/23

Laboratory Topic
Textbook
  •  Ch. 16, pp. 251-261
    • Anemias- Introduction
Lecture Topics
Assignment
  • Admission Ticket: Hypochromic Anemias. Found in Bb under assignments tab. Due 9/7/23
  • Hematology Math. Submit to Dropbox in Bb. Due 9/10/23
  • MediaLab WBC Case #3 . Due 9/10/23

Thursday 9/7/23

Laboratory Topics
Textbook
  • Ch. 8, pp. 105-112
    • Iron
  • Ch. 17, pp. 264-277
    • Disorders of Iron Kinetics & Heme Metabolism
Lecture Topics
  • Review Exam 1, as needed
  • Iron Metabolism and Hypochromic Anemias | Objectives | Notes
Assignment
  • PL: RBC Morphology on Peripheral Smear. Pre-lab is found in Bb under assignments tabDue 9/13/23
  • Admission Ticket: Macrocytic and Aplastic Anemias. Found in Bb under assignments tab. Due 9/13/23

Wednesday 9/13/23

Laboratory Topics
Textbook
  • Ch.18, pp. 282-296
    • Macrocytic Anemia
  • Ch. 19, pp. 299-311
    • Bone Marrow Failure
Lecture Topics
Assignment
  • PL: RBC Morphology & Auto CBC Correlation. Pre-lab is found in Bb under assignments tabDue 9/14/23
  • Case study #1: Found in Bb under assignments, in Hematology case studies. Due 9/21/22 @ 11:55 pm
  • MediaLab WBC Case #1. Due 9/17/23

Thursday 9/14/23

Laboratory Topics
Textbook
  • Ch. 20, pp. 316-333
    • Introduction to Hemolytic Anemias
  • Ch. 21, pp. 336-359
    • Intrinsic Defects Affecting RBCs
Lecture Topics
Assignment
  • Watch video on Intravascular Hemolysis (~10 minutes long)
  • Watch video on Extravascular Hemolysis (~10 minutes long)
  • PL: WBC & PLT estimates/inclusions: Pre-lab is found in Bb under assignments tab. Due 9/20/23
  • Admission Ticket: Hemolytic Anemias/Enzyme Deficiency: Found in Bb under assignments tab. Due 9/20/23

Wednesday 9/20/23

Laboratory Topics
Textbook
  • NA
Lecture Topics
Assignment
  • MediaLab WBC Case #10. Due 9/24/23

Thursday 9/21/23

Laboratory Topics
  • Atlas Review: Normal WBCs
  • Sysmex Activity
Textbook
  • Ch. 23, pp. 378-390
    • Extrinsic Defects Affecting RBCs- Immune
Lecture Topics
  • Review Exam 2, as needed
  • Hemolytic Anemias: Immune Anemias | Objectives | Notes
Assignment
  • PL Counting to 100: Pre-lab is found in Bb under assignments tab. Due 9/27/23

Wednesday 9/27/23

Laboratory Topics
Textbook
  • Ch. 22, pp. 363-374
    • Extrinsic Defects Affecting RBCs- Nonimmune
Lecture Topics
Assignment
  • Admission Ticket: Hemoglobinopathies and Thalassemias. Found in Bb under assignments tab. Due 9/28/23
  • PL: Manual Differentials. Pre-lab is found in Bb under assignments tab. Due 9/28/23
  • MediaLab WBC Case #13. Due 10/1/23
  • Watch this video for an Introduction to Thalassemia.
  • Optional: Watch this video illustrating one example of nonimmune hemolytic anemia

Thursday 9/28/23

Laboratory Topics
Textbook
  • Ch. 24, pp. 394-420
    • Hemoglobinopathies
  • Ch. 25, pp. 424-442
    • Thalassemias
Lecture Topics
Assignment
  • Watch this video on Alpha Thalassemia.
  • Watch this video on Beta Thalassemia.
  • Admission Ticket: Granulocyte, Monocyte, and Nonmalignant Lymph Disorders. Found in Bb under assignments tab. Due 10/4/23
  • Case Study #2: Found in Bb, under assignments, in Hematology case studies. Due 10/5/22 @ 11:55 pm
  • MediaLab WBC Case #7 and #25. Due 10/1/23

Wednesday 10/4/23

Laboratory Topics
Textbook
  • Ch. 26, pp. 445-462
    • Non-Malignant WBC Disorders
Lecture Topics
Assignment

Thursday 10/5/23

Laboratory Topics
Textbook
  • Ch. 27, pp. 466-475
    • Introduction to Hematologic Malignancies
Lecture Topics
  • Review Exam 3, as needed
  • Introduction to Hematopoietic Neoplasms | Objectives | Notes
Assignment
  • Admission Ticket: Myeloproliferative Disorders. Found in Bb under assignments tab. Due 10/11/23
  • MediaLab WBC Case #5 and #8. Due 10/8/23

Wednesday 10/11/23

Laboratory Topics
  • Morphology Checklist: Abnormals/Immature, if needed
Textbook
  • Ch. 32, pp. 555-582
    • Myeloproliferative Disorders
  • Ch. 33, pp. 589-598
    • Myelodysplastic Syndromes
Lecture Topics
Assignment
  • Admission Ticket: Acute Lymphocytic Leukemia. Found in Bb under assignments tab. Due 10/12/23
  • Case Study #3. Found in Bb, under assignments, in Hematology case studies. Due 10/18/23 @ 11:55 pm
  • MediaLab WBC Case #2. Due 10/15/23

Thursday 10/12/23

Laboratory Topic
Textbook
  • Ch. 31, pp. 540-552
    • Acute Leukemias
Lecture Topic
Assignment
  • MediaLab WBC Case #11. Due 10/15/23

Wednesday 10/18/23

Laboratory Topic
Textbook
  • Ch. 34, pp. 603-622
    • Mature Lymphoid Neoplasms
Lecture Topics
Assignment
  • N/A

Thursday 10/19/23

Topic
  • TBA
Textbook
  • N/A
Laboratory
Assignment
  • N/A

Wednesday 10/25/23

Topic
  •  Course Practical Exam
  • Review Exam 5, as needed
Textbook
  • N/A
Laboratory
  • N/A
Assignment
  • N/A

Thursday 10/26/23

Topic
  •  Course Final Exam
Textbook
  • N/A
Laboratory
  • N/A
Assignment
  • N/A

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