MLAB 1227: Coagulation

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MLAB 1227: Coagulation

Dates: November 3- Dec. 14, 2025
Length of Course: 5 Weeks

Total Number of Hours: 48 Contact Hours

A course in coagulation theory, procedures, and practical applications. Includes quality control, quality assurance, safety and laboratory procedures which rely on commonly performed manual and/or semi-automated methods.

Course Objectives

By the end of this course the student should be able to:

Apply principles of safety, quality assurance and quality control in coagulation.
Evaluate specimen acceptability and dispose of them in the appropriate biohazard containers.
Compare and contrast coagulation processes under normal and abnormal human conditions.
Perform basic laboratory Coagulation analysis
Evaluate laboratory test results and correlate with patient conditions(s).
Demonstrate compliance with OSHA safety regulations for blood –borne pathogens.

Syllabus

Please print the MLAB 1227 Syllabus and bring it to class.

Textbook

Keohanne, Elaine M., Preston, Michelle M., Mirza, Kamran M., and Walenga Jeanine M., Rodak’s Hematology:
Clinical Principles and Applications, Seventh Edition, Elsevier, ISBN 978-0-323-93607

Assessment Dates

Quiz 1 In class	Covers Chapters 11 (Platelets) and35 (Normal Hemostasis) Overview of Hemostasis and Platelet Physiology Secondary Hemostasis: Coagulation Factors Intrinsic, Extrinsic, Common Pathways	Thursday, November 6, 2025
Quiz 2	Covers Chapter 42- section on the TEG & TEG video	Opens: Wednesday, November 12, 2025	Closes: Sunday, November 16, 2025
Quiz 3 In class	Covers Chapter 37 (Disorders of Platelets & Vasculature)	Thursday, November 13, 2025
Exam 1 Remote	Covers: Chapters 11 (Platelets), 35( Normal Hemostasis), 41( Lab Evaluation of Hemostasis), and 42 (Hemostasis & Coagulation Instrumentation)Labs: Pre-analytical issues and coagulation automation	Opens: Friday, November 14, 2025 at 7 am	Closes: Sunday, November 16, 2025 at 8 pm
Quiz 4 In class	Covers Chapter 36 (Disorders of Secondary Hemostasis)	Wednesday, November 19, 2025
Quiz 5 In class	Covers Chapter 38 (Quantitative Disorders of Platelets)	Thursday, November 20, 2025
Quiz 6	Covers Chapter 39 (Thrombotic Disorders and Lab Assessment)	Monday, November 24, 2025
Practical Exam On Campus	Covers all labs, including Coagulation Automation and Lab Testing in Coagulation PPTs	EVC: Wednesday, December 3, 2025 8:30-10:30 am Room 8301	RRC: Wednesday, December 3, 2025 3:30-5:30 pm Room 3121.00
Final On Campus	Covers all lecture material	EVC: Thursday, December 4, 2025 8:30- 10:30 am Room 2307	RRC: Thursday, December 4, 2025 3:30- 5:30 pm Room 3121.00

Schedule

Admission tickets (ATs) and Pre-labs (PLs) are due by 8:30 a.m on the day the material is covered.

Week of 10/27/2025

Topic	N/A
Textbook	N/A
Laboratory	N/A
Assignment	Pre-Lab Assessment: Hemostasis Testing; found in Bb under Assignments button in the lecture admission tickets folder. Due 11/5/2025 Pre-Lab Assessment: Bleeding time. Found in Bb under the Assignments button in the Pre-Lab folder. Due 11/5/2025 Admission ticket: Overview of Hemostasis and Platelet Physiology. Found in Bb under Assignments button in the lecture admission tickets folder. Due 11/5/2025 Take the Respondus practice quiz in the Coagulation Blackboard course. This is to ensure your computer and camera are working properly prior to the first exam. Due 11/13/2025 Please review this tutorial of how the blood clots. ( 5 minutes)

11/5/2025

Lecture Topics	Syllabus Review, Q & A Overview of Hemostasis and Platelet Physiology \| Objectives \| Hemostasis Part 1 \| The Platelets \| Hemostasis Part 2 Pre-analytical Issues in Coagulation Testing l Objectives \| Notes
Textbook	Ch. 11, pp. 159-175 Platelet Production, Structure, and Function Ch. 35, pp. 661-666 Normal Hemostasis Ch. 42, pp. 841-854, 855-857 (Platelet Function Testing) Hemostasis and Coagulation Instrumentation
Laboratory	Laboratory Testing in Coagulation \| Objectives \| Notes Hemostasis & Coagulation Automation \| Objectives \| Notes Lab: Bleeding Time
Assignment	Pre-Lab Assessment: Prothrombin Time (PT)/INR. Found in Bb under the Assignments button in the Pre-Lab folder. Due 11/6/2025 Preanalytical Case Studies in Bb under Assignments button, in the “Class activities” folder. Due by 11/9/2025 Helpful handouts for Secondary Hemostasis: Characteristics of Hemostatic Proteins \| Secondary Hemostasis – Y-shaped Pathways Additional handouts: Intrinsic and Extrinsic Coagulation Process \| Coagulation Overview – Vessel Damage

11/6/2025

Lecture Topics	Secondary Hemostasis: Coagulation Factors Intrinsic, Extrinsic, Common Pathways \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 35, pp. 666-673 Normal Hemostasis Ch. 41, pp. 821-824 (PT) Laboratory Evaluation of Hemostasis
Laboratory	Lab: Prothrombin Time & INR
Assignment	Admission ticket: Fibrinolysis and Physiologic Hemostasis; found in Bb under Assignments button in the lecture admission tickets folder. Due 11/12/2025 Watch the video “Warfarin” (15 minutes)

11/12/2025

Lecture Topics	Fibrinolysis \| Objectives \| Notes Physiologic Control of Hemostasis \| Objectives \| Notes
Textbook	Ch. 35, pp. 676-683 Normal Hemostasis Ch. 41, pp. 811-817, 826-827 (thrombin time) Laboratory Evaluation of Hemostasis
Laboratory	Lab: Thrombin Time
Assignment	Watch the Hemostasis, Coagulation, and Fibrinolysis video. (4 minutes) Pre-Lab Assessment: aPTT; found in Bb under the Assignments button in the Pre-Lab folder. Due 11/13/2025 Admission ticket: Primary Disorders; found in Bb under assignments button in the lecture admission tickets folder. Due 11/13/2025 Homework: TEG Video and Quiz; Review the video here and take the TEG quiz found in Blackboard, under the Exam button, in the “Exams/Quiz” folder in the “Quizzes” folder. Due 11/16/2025 Handout: Diagnostic Approach to Bleeding

11/13/2025

Lecture Topic	Coagulation Disorders: Primary Hemostasis \| Objectives \| Notes
Textbook	Ch. 37, pp. 713-729 Qualitative Disorders of Platelets and Vasculature Ch. 41, pp. 824-826 (PTT) Laboratory Evaluation of Hemostasis
Laboratory	Lab: PTT
Assignment	Pre-Lab Assessment: Fibrinogen; found in Bb under the Assignments button. Due 11/19/2025 Admission ticket: Secondary Disorders; found in Bb under assignments button. Due 11/19/2025 Homework: Inherited Platelet Defects; Due 11/16/2025 Navigate to the “Dropbox” in Bb, select the “Homework” folder, upload assignment. Watch the video “Heparin” (14 minutes) Watch the video “Heparin vs. Warfarin” (12 minutes.)

11/19/2025

Lecture Topic	Review Exam #1 as needed. Coagulation Disorders: Secondary Hemostasis \| Objectives \| Notes Part 1 \| Part 2
Textbook	Ch. 36, pp. 686-707 Hemorrhagic Disorders and Lab Assessment Ch. 39, pp. 775-778 (DIC) Laboratory Evaluation of Hemostasis
Laboratory	Lab: Fibrinogen
Assignment	Admission ticket: Thrombocytopenia & Thrombocytosis; found in Bb under Assignments button in the lecture admission tickets folder. Due 11/20/2025

11/20/2025

Topic	Thrombocytopenia & Thrombocytosis \| Objectives \| Notes
Textbook	Ch. 38, pp. 734-755 Quantitative Disorders of Platelets: Thrombocytopenia and Thrombocytosis
Laboratory	Mixing Study Bring your copy of the PT and aPTT labs.
Assignment	Admission ticket: Thrombotic Disorders; found in Bb under assignments button in the lecture admission tickets folder. Due 11/24/2025 Pre-Lab Assessment: D-dimer; found in Bb under the Assignments button in the Pre-Lab folder. Due 11/24/2025

11/24/2025

Topic	Thrombotic Disorders \| Objectives \| Notes
Textbook	Ch. 39, pp. 761-782 Thrombotic Disorders and Lab Assessment Ch. 41, pp. 831-832 (D-dimer) Laboratory Evaluation of Hemostasis
Laboratory	Lab: D-dimer
Assignment	Thrombophilia Crossword. Navigate to the “Dropbox” in Bb, select the “Homework” folder, upload assignment. Due 11/26/2025

12/3/2025

Topic	TBA
Textbook
Laboratory	Lab Practical
Assignment

12/4/2025

Topic	Course Final Exam
Textbook
Laboratory
Assignment

12/8/2025

Topic	Complete Coagulation Student Course Evaluation Your feedback matters! Evaluation period closes on 12/15/2025.
Textbook
Laboratory
Assignment

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