MLAB 2401: Clinical Chemistry


MLAB 2401: Clinical Chemistry

  • Dates: May 30 – August 6, 2023
  • Length of Course: 10 Weeks
  • Classroom Hours: 48 (approximate)
  • Laboratory Hours: 64 (approximate)

An introduction to the principles and procedures of various tests performed on Clinical Chemistry. Presents the physiological basis for the test, the principle and procedure for the test, and the clinical significance of the test results, including quality control and normal values. Also includes basic chemical laboratory technique, chemical laboratory safety, electrolytes and acid-base balance, proteins, carbohydrates, lipids, enzymes, metabolites, endocrine function, and toxicology.

Upon successful completion of this course, the student should be able to:

  1. Exhibit a knowledge of body chemistry levels under healthy or abnormal conditions.
  2. Properly evaluate the suitability of clinical chemistry specimens.
  3. Properly prepare chemistry specimens for analysis.
  4. Explain and perform procedures routinely found in a clinical chemistry laboratory, including electrolytes, acid-base balance, proteins, enzymes, carbohydrates, lipids, toxicology, therapeutic drug monitoring, and liver, kidney, and endocrine functions.
  5. Evaluate laboratory test outcomes and correlate test results with patient condition(s).
  6. Accurately record and report results, indicating normal and abnormal values.
  7. Evaluate quality control results and note trends, shifts and invalid results.
  8. Demonstrate speed and accuracy in the analysis of chemistry specimens for the following types of procedures utilizing only necessary supplies and within a predetermined, reasonable amount of time:
    • weights and measures
    • reagent preparation and use
    • color spectrophotometric
    • coulometric titration
    • enzymatic
    • electrophoretic
    • other test procedures as available
  9. Explain the principles of the above procedures and describe the clinical importance of abnormal results.
  10. Discuss recent trends in clinical chemistry.

Please print the MLAB 2401 Syllabus and bring it to class.

Bishop, Michael L., Fody, Edward P., and Schoeff, Larry, Clinical Chemistry, Ninth Edition, Jones & Bartlett Learning, ISBN 978-1-284-23886-0

Exam 1

(Remote)

Covers: Quality Control & Statistics, Basic Principles & Practice, Lab Safety & Regulations, Electrochemistry, Electrolytes, Mineral & Bone, Carbohydrates, and Trace Elements

Labs: QC, Safety, Micropipet/pipetting,  Osmometry, Minerals, Automation, Atomic Absorption Spectrophotometry, and Spectrophotometry

Opens: Thursday, June 15, 2023, at 7 a.m. Closes: Sat., June 17, 2023, at 7 p.m.
Exam 2 

(In class)

Covers: Proteins & Amino Acids, and Endocrinology.

Labs:  Electrophoresis

EVC:

Monday, June 26, 2023

8:30 – 9:45 am

Room 9317

RRC:

Monday, June 26, 2023

3:30- 4:45 pm

Room 3121

Exam 3

(In Class)

Covers: pH and Acid/Base Imbalance, Hemoglobin Production Disorders, Renal Function, and Tumor Markers.

Labs: Point of Care, and Designs in Automation

EVC:

Monday, July 10, 2023

8:30 – 10:00 am

Room 9317

RRC:

Monday, July 10, 2023

3:30- 5:00 pm

Room 3121

Exam 4

(Remote)

Covers: Enzymes, Liver, TDM, Toxicology, Lipids, and Cardiac Function

Labs: Lipids, Liver, and Toxicology

Opens: Thursday, July 27, 2023, at 7 a.m. Closes: Sat., July 29, 2023, at 7 p.m.

Comprehensive Final Exam – July 31, 2023

EVC Room 9317 9:00- 11:00 am.

RRC Room 3121.00 3:30-5:30 pm.

  • Please note- do  NOT print directly from the pDFs.  Make sure to download the document first, then print.

Week of 5/22/23

Laboratory
  • NA
Lecture Topics
Textbook
  • Ch. 2, pp. 38-55: Laboratory Safety and Regulations
  • Ch. 3, pp. 57-87: QA, Quality Control, and Statistics
Assignment
  • Read course syllabus.
  • Admission ticket: Quality Control. This can be found under “Assignments” in Blackboard. Due 5/30/23
  • Pre-Lab Assessment: Safety. Found in Bb under the Assignments button in the Pre-Lab folder. Due 5/30/23
  • Pre-Lab Assessment: Pipetting/Micropipette Cal. Found in Bb under the Assignments button in the Pre-Lab folder. Due 5/30/23

Tuesday 5/30

Laboratory
Lecture Topics
Textbook
  • Ch. 1, pp. 2-35: Basic Principles & Practice
  • Ch. 4, pp. 102-107: Electrochemistry
Assignment
  • Lab: Quality Control
    • Virtual lab
    • Lab & SQs Due 6/2/23
  • Pre-Lab Assessment: Osmolality. Found in Bb under Assignments button in the Pre-Lab folder. Due 6/5/23
  • Admission ticket: Electrolytes. This can be found under “Assignments” in Blackboard. Due 6/5/23
  • Pre-Lab Assessment: Automation. Found in Bb under the Assignments button in the Pre-Lab folder. Due 6/5/23

Monday 6/5

Laboratory
Lecture Topics
Textbook
  • Ch. 11, pp. 316-346: Electrolytes
  • Ch. 18, pp. 469-483: Mineral and Bone Metabolism
Assignment

Tuesday 6/6

Laboratory
Lecture Topics
Textbook
  • Ch. 27, pp. 669-690: Trace Elements
Assignment
  • Admission ticket: Carbohydrates. This can be found under “Assignments” in Blackboard. Due 6/12/23
  • Trace Elements Crossword

Monday 6/12

Laboratory
Lecture Topics
Textbook
  • Ch. 9, pp. 260-281: Carbohydrates
Assignment
  • Admission ticket: Proteins and Amino Acids. This can be found under “Assignments” in Blackboard. Due 6/13/23

Tuesday 6/13

Laboratory
  • TBA
Lecture Topics
Textbook
  • Ch. 6, pp. 162-203: Proteins and Amino Acids
Assignment
  • Pre-Lab Assessment: Electrophoresis. Found in Bb under the Assignments button in the Pre-Lab folder. Due 6/20/23

Monday 6/19

Laboratory
  • HOLIDAY- ACC Closed
Lecture Topics
  • Electrophoresis | Objectives | Notes
    • This is a self-instructional unit. Material will not be reviewed in class.
Textbook
  • Ch. 4, 107-111: Analytic Techniques
  • Ch. 6, pp. 188-194:Proteins & Heme Derivatives
Assignment
  • Admission ticket: Endocrinology. This can be found under “Assignments” in Blackboard. Due 6/20/23
  • Complete Electrophoresis Study Questions.
    • Due 6/23/23

Tuesday 6/20

Laboratory
Lecture Topics
Textbook
  • Ch. 13, pp. 370- 392: Introduction to Endocrinology
  • Ch. 14, pp. 395-408: Endocrine- Thyroid Function
  • Ch. 15, pp. 410-423: Endocrine- Hypothalamic & Pituitary
  • Ch. 16, pp. 426-444: Endocrine- Endocrine Adrenal
  • Ch. 17, pp. 447-465: Endocrine- Gonadal
Assignment
  • Admission ticket: Hemoglobin Production Disorders. This can be found under “Assignments” in Blackboard. Due 6/26/23
  • Admission ticket: Renal Disorders. This can be found under “Assignments” in Blackboard. Due 6/26/23

Monday 6/26

Laboratory
Lecture Topics
Textbook
  • Ch. 6, pp. 198-203:Hemoglobin Production Disorders
  • Ch. 21, pp. 539-565: The Kidney and Test of Renal Function
Assignment
  • Admission ticket: pH and Acid-base Imbalance. This can be found under “Assignments” in Blackboard. Due 6/27/23

Tuesday 6/27

Laboratory
  • Acid/Base Disorders Worksheet
  • Point of Care Testing (POCT) | Objectives | Notes
Lecture Topics
Textbook
  • Ch. 12, pp. 348-367: pH and Acid-base Imbalance
  • Ch. 29, pp. 725-732: Point of Care Testing (POCT)
Assignment
  • TBA

Monday 7/3

Laboratory
Lecture
  • This is a self-instructional unit. Material will not be reviewed in class.
Textbook
  • Ch. 28, pp. 703-721: Tumor Markers
Assignment

Tuesday 7/4

Textbook
  • ACC CLOSED- HOLIDAY
Laboratory
  • N/A
Assignment
  • Admission ticket: Enzymes. This can be found under “Assignments” in Blackboard. Due 7/10/23

Monday 7/10

Textbook
Laboratory
Assignment
  • Ch. 8, pp. 225-258 Enzymes
  • Admission ticket: Liver Function. This can be found under “Assignments” in Blackboard. Due 7/11/23

Tuesday 7/11

Laboratory
Lecture
Textbook
  • Ch. 19, pp. 486-512: Liver Function
Assignment
  • Complete the Liver Function & Evaluation Crossword
    • Upload to the Dropbox
    • Due 7/16/23 
  • Admission ticket: TDM/Toxicology. This can be found under “Assignments” in Blackboard. Due 7/17/23
  • Review tutorial “The A, B, C’s of Hepatitis” located in Bb under the Resources/Tutorials button in the Liver folder.

Monday 7/17

Laboratory
Lecture
Textbook
  • Ch. 25, pp. 622-644: Therapeutic Drug Monitoring (TDM)
  • Ch. 26, pp. 646-668: Toxicology
Assignment

Tuesday 7/18

Laboratory
Lecture
Textbook
  • Ch. 10, pp. 286-312: Lipids and Lipoproteins
Assignment
  • Admission ticket: Cardiac Monitoring and Lipids. This can be found under “Assignments” in Blackboard. Due 7/24/23

Monday 7/24

Laboratory
Lecture
Textbook
Assignment

Tuesday 7/25

Textbook
Laboratory
Assignment

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