MLAB 2401: Clinical Chemistry

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MLAB 2401: Clinical Chemistry

Dates: May 28 – August 4, 2024
Length of Course: 10 Weeks
Classroom Hours: 48 (approximate)
Laboratory Hours: 64 (approximate)

An introduction to the principles and procedures of various tests performed on Clinical Chemistry. Presents the physiological basis for the test, the principle and procedure for the test, and the clinical significance of the test results, including quality control and normal values. Also includes basic chemical laboratory technique, chemical laboratory safety, electrolytes and acid-base balance, proteins, carbohydrates, lipids, enzymes, metabolites, endocrine function, and toxicology.

Course Objectives

Upon successful completion of this course, the student should be able to:

Exhibit a knowledge of body chemistry levels under healthy or abnormal conditions.
Properly evaluate the suitability of clinical chemistry specimens.
Properly prepare chemistry specimens for analysis.
Explain and perform procedures routinely found in a clinical chemistry laboratory, including electrolytes, acid-base balance, proteins, enzymes, carbohydrates, lipids, toxicology, therapeutic drug monitoring, and liver, kidney, and endocrine functions.
Evaluate laboratory test outcomes and correlate test results with patient condition(s).
Accurately record and report results, indicating normal and abnormal values.
Evaluate quality control results and note trends, shifts and invalid results.
Demonstrate speed and accuracy in the analysis of chemistry specimens for the following types of procedures utilizing only necessary supplies and within a predetermined, reasonable amount of time:
- weights and measures
- reagent preparation and use
- color spectrophotometric
- coulometric titration
- enzymatic
- electrophoretic
- other test procedures as available
Explain the principles of the above procedures and describe the clinical importance of abnormal results.
Discuss recent trends in clinical chemistry.

Syllabus

Please print the MLAB 2401 Syllabus and bring it to class.

Textbook

Bishop, Michael L., Fody, Edward P., and Schoeff, Larry, Clinical Chemistry, Ninth Edition, Jones & Bartlett Learning, ISBN 978-1-284-23886-0

Exams

Exam 1

(On campus)

Covers: Quality Control & Statistics, Basic Principles & Practice, Lab Safety & Regulations, Electrochemistry, Electrolytes, Mineral & Bone, Carbohydrates, and Trace Elements

Labs: QC, Safety, Micropipet/pipetting, Osmometry, Minerals, Automation, Atomic Absorption Spectrophotometry, and Spectrophotometry

EVC: Monday, June 17, 2024

8:30 – 9:45 am

Room 9317

RRC: Monday, June 17, 2024

3:30- 4:45 pm

Room 3121

Exam 2

(On campus)

Covers: Proteins & Amino Acids, and Endocrinology.

Labs: Electrophoresis

EVC: Monday, June 24, 2024

8:30 – 9:45 am

Room 9209

RRC: Monday, June 24, 2024

3:30- 4:45 pm

Room 3121

Exam 3

(On campus)

Covers: pH and Acid/Base Imbalance, Hemoglobin Production Disorders, Renal Function, and Tumor Markers.

Labs: Point of Care, and Designs in Automation

EVC: Monday, July 8, 2024

8:30 – 10:00 am

Room 9209

RRC: Monday, July 8, 2024

3:30- 5:00 pm

Room 3121

Exam 4

(Remote)

Covers: Enzymes, Liver, TDM, Toxicology, Lipids, and Cardiac Function

Labs: Lipids, Liver, and Toxicology

Opens: Monday, July 22, 2024, at 7 a.m.

Closes: Tuesday, July 23, 2024, at 7 p.m.

Comprehensive Final Exam – Monday, July 29, 2024

EVC Room 9209 9:00- 11:00 am.

RRC Room 3121.00 3:30-5:30 pm.

Schedule

Please note- do NOT print directly from the pDFs. Make sure to download the document first, then print.

Week of 5/20/24

Laboratory	NA
Lecture Topics	This is a self-instructional unit. Material will not be reviewed in class. Laboratory Safety and Regulations \| Objectives \| Notes QA, Quality Control, and Statistics \| Objectives \| Notes Westgard System and Rules When Chemistry QC Is Out Flowchart (PDF)
Textbook	Ch. 2, pp. 38-55: Laboratory Safety and Regulations Ch. 3, pp. 57-87: QA, Quality Control, and Statistics
Assignment	Read course syllabus. Admission ticket: Quality Control. This can be found under “Assignments” in Blackboard. Due 5/28/24 Pre-Lab Assessment: Safety. Found in Bb under the Assignments button in the Pre-Lab folder. Due 5/28/24 Pre-Lab Assessment: Pipetting/Micropipette Cal. Found in Bb under the Assignments button in the Pre-Lab folder. Due 5/28/24

Tuesday 5/28/24

Laboratory	Syllabus Review-collect signature sheets Lab: Safety Biowaste Guide (PDF) Lab: Micropipette & Pipetting
Lecture Topics	Basic Principles & Practice \| Objectives \| Notes Part 1 \| Part 2 Guided Practice: Chemistry Math Electrochemistry \| Objectives \| Notes
Textbook	Ch. 1, pp. 2-35: Basic Principles & Practice Ch. 4, pp. 102-107: Electrochemistry
Assignment	Lab: Quality Control Virtual lab Lab & SQs Due 5/31/24 Pre-Lab Assessment: Osmolality. Found in Bb under Assignments button in the Pre-Lab folder. Due 6/3/24 Admission ticket: Electrolytes. This can be found under “Assignments” in Blackboard. Due 6/3/24 Pre-Lab Assessment: Automation. Found in Bb under the Assignments button in the Pre-Lab folder. Due 6/4/24 Admission ticket: Mineral and Bone. This can be found under “Assignments” in Blackboard. Due 6/4/24 Chemistry Mathematics #1: Conversion & Dilutions Due 6/9/24 Chemistry Mathematics #2: Molarity, Normality, Concentration Due 6/9/24

Monday 6/3/24

Laboratory	Lab: Osmometry
Lecture Topics	Electrolytes \| Objectives \| Notes Part 1 \| Part 2
Textbook	Ch. 11, pp. 316-346: Electrolytes
Assignment	Videos Related to Water Balance- highly recommended! Osmosis, Osmotic pressure, Osmolality Osmolality vs. Osmolarity

Tuesday 6/4/24

Laboratory	Automation \| Objectives \| Notes Lab: Mineral Determination
Lecture Topics	Mineral and Bone Metabolism \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 18, pp. 469-483: Mineral and Bone Metabolism
Assignment	Pre-Lab Assessment: Spectrophotometry. Found in Bb under the Assignments button in the Pre-Lab folder. Due 6/10/24

Monday 6/10/24

Laboratory	Electromagnetic Radiation & Spectrophotometry \| Objectives \| Notes Atomic Absorption Spectrophotometry \| Objectives \| Notes Lab: Spectrophotometry Virtual lab Lab & SQs Due 6/14/24
Lecture Topics	Trace Elements \| Objectives Trace Elements Table Review Math Assignments, as needed.
Textbook	Ch. 27, pp. 669-690: Trace Elements
Assignment	Admission ticket: Carbohydrates. This can be found under “Assignments” in Blackboard. Due 6/11/24 Trace Elements Crossword Due 6/16/24

Tuesday 6/11/24

Laboratory	ACE Alera Overview (Google Slides) Lab: ACE Axcel Getting Started
Lecture Topics	Carbohydrates \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 9, pp. 260-281: Carbohydrates
Assignment	Admission ticket: Proteins and Amino Acids. This can be found under “Assignments” in Blackboard. Due 6/17/24

Monday 6/17/24

Laboratory	Technical Support
Lecture Topics	Proteins and Amino Acids \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 6, pp. 162-203: Proteins and Amino Acids
Assignment	Pre-Lab Assessment: Electrophoresis. Found in Bb under the Assignments button in the Pre-Lab folder. Due 6/18/24 Admission ticket: Endocrinology. This can be found under “Assignments” in Blackboard. Due 6/18/24

Tuesday 6/18/24

Laboratory	Electrophoresis \| Objectives \| Notes
Lecture Topics	Exam #1Review, as needed. Endocrinology \| Objectives \| Notes Part 1: Introduction to Endocrinology \| Part 2: Adrenals- Overview\| Part 3: Adrenals- Disorders \| Part 4: Thyroid
Textbook	Ch. 4, 107-111: Analytic Techniques Ch. 6, pp. 188-194: Proteins & Heme Derivatives (Electrophoresis) Ch. 13, pp. 370- 392: Introduction to Endocrinology Ch. 14, pp. 395-408: Endocrine- Thyroid Function Ch. 15, pp. 410-423: Endocrine- Hypothalamic & Pituitary Ch. 16, pp. 426-444: Endocrine- Endocrine Adrenal Ch. 17, pp. 447-465: Endocrine- Gonadal
Assignment	Complete Electrophoresis Study Questions. Due 6/21/24 Admission ticket: Hemoglobin Production Disorders. This can be found under “Assignments” in Blackboard. Due 6/24/24 Admission ticket: Renal Disorders. This can be found under “Assignments” in Blackboard. Due 6/24/24

Monday 6/24/24

Laboratory	Lab: Other Designs in Automation
Lecture Topics	The Kidney and Test of Renal Function \| Objectives \| Notes Part 1 \| Part 2 \| Part 3 Hemoglobin Production Disorders \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 6, pp. 198-203:Hemoglobin Production Disorders Ch. 21, pp. 539-565: The Kidney and Test of Renal Function
Assignment	Admission ticket: pH and Acid-base Imbalance. This can be found under “Assignments” in Blackboard. Due 6/25/24

Tuesday 6/25/24

Laboratory	Acid/Base Disorders Worksheet Point of Care Testing (POCT) \| Objectives \| Notes
Lecture Topics	Exam #2 Review , as needed. pH and Acid-base Imbalance \| Objectives \| Notes Part 1 \| Part 2 \| Part 3 \| Part 4 Classification of Acid-base Disorders (PDF) Siggaard-Andersen Nomograph (PDF)
Textbook	Ch. 12, pp. 348-367: pH and Acid-base Imbalance Ch. 29, pp. 725-732: Point of Care Testing (POCT)
Assignment	TBA

Monday 7/1/24

Laboratory	Note: Students will NOT come to campus
Lecture	This is a self-instructional unit. Material will not be reviewed in class. Tumor Markers \| Objectives \| Notes
Textbook	Ch. 28, pp. 703-721: Tumor Markers
Assignment	Admission ticket: Enzymes. This can be found under “Assignments” in Blackboard. Due 7/2/24

Tuesday 7/2/24

Laboratory	TBA
Lecture	Enzymes \| Objectives \| Notes Part 1 \| Part 2
Textbook	Ch. 8, pp. 225-258 Enzymes
Assignment	Admission ticket: Liver Function. This can be found under “Assignments” in Blackboard. Due 7/8/24

Monday 7/8/24

Laboratory	Lab: Liver Enzymes
Lecture	Liver Function \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 19, pp. 486-512: Liver Function
Assignment	Complete the Liver Function & Evaluation Crossword Upload to the Dropbox Due 7/14/24 Admission ticket: TDM/Toxicology. This can be found under “Assignments” in Blackboard. Due 7/9/24 Review tutorial “The A, B, C’s of Hepatitis” located in Bb under the Resources/Tutorials button in the Liver folder.

Tuesday 7/9/24

Laboratory	Lab: Toxicology
Lecture	Review Exam #3, as needed. Therapeutic Drug Monitoring (TDM) \| Objectives \| Notes Toxicology \| Objectives \| Notes Part 1 \| Part 2
Textbook	Ch. 25, pp. 622-644: Therapeutic Drug Monitoring (TDM) Ch. 26, pp. 646-668: Toxicology
Assignment	Read article: Mysteries of medical marijuana are challenge for doctors. Log into Bb, go to the discussion board, and post your opinions of this article in at least 50 words. Due 7/14/24

Monday 7/15/24

Laboratory	Lab: Lipid Studies
Lecture	Lipids and Lipoproteins \| Objectives \| Notes Part 1 \| Part 2 \| Part 3
Textbook	Ch. 10, pp. 286-312: Lipids and Lipoproteins
Assignment	Admission ticket: Cardiac Monitoring and Lipids. This can be found under “Assignments” in Blackboard. Due 7/16/24

Tuesday 7/16/24

Laboratory
Lecture	Cardiovascular Conditions and Assessment \| Objectives \| Notes
Textbook
Assignment	Cardiac Marker Worksheet: submit to Dropbox in Bb. Due 7/21/24

Monday 7/22/24

	TBD
Textbook
Laboratory
Assignment

Tuesday 7/23/24

	TBD
Textbook
Laboratory
Assignment

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