MLAB 2431: Immunohematology

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MLAB 2431: Immunohematology

Dates: Jan. 20- May 17, 2026
Length of Course: 16 Weeks
Classroom Hours: 48 (hybrid)
Laboratory Hours: 64

Immunohematology is a specialized branch of laboratory medicine which involves the study of blood group antigens and antibodies. The processes of quality testing include quality control, basic laboratory techniques and safety. It involves the study of the principles, procedures, clinical significance and practice of a wide variety of procedures including: donor selection, component preparation and use, and techniques used to detect antigen/antibody reactions which may adversely affect a patient receiving a transfusion. The topics to be covered include: donor screening, preparation of components, antigens and antibodies of the ABO, Rh and other blood group systems, pretransfusion testing procedures, hemolytic disease of the fetus and newborn, neonatal and obstetrical transfusion practice, autoimmune hemolytic anemias and adverse affects of transfusion.

Course Objectives

Apply the principles of safety, quality assurance, and quality control in immunohematology.
Describe the blood collection process.
State the preparation method, use, storage requirements, and expiration of each blood component.
Evaluate specimen acceptability.
State the principle of each testing procedure performed in Immunohematology.
State the characteristics of the ABO, Rh, and other blood group systems.
List the methods used to identify the most commonly encountered blood group antibodies.
Describe the three types of hemolytic disease of the fetus and newborn (HDFN).
Describe the testing, antibody specificity, and treatment for HDFN.
List the adverse complications of blood transfusion.
State the methods for evaluating a positive direct antiglobulin test.
State the types of immune hemolytic anemias including results of serologic testing and compatibility testing which must be performed.
State the requirements for performing compatibility testing.
Describe the quality control performed in Immunohematology.
Explain the next steps when the quality controls are out of range in Immunohematology.
Describe the immune process as it relates to Immunohematology.
Describe the donor selection process and accurately determine donor eligibility when given results of donor screening tests.
Describe the preparation and the appropriate use of blood components by determining the component needed based on laboratory data.
Describe the characteristics of the antigens and antibodies of the ABO, Rh, and other blood group systems, applying the knowledge to sample testing and case study materials.
Perform blood bank testing in the resolution of antibody problems, HDFN, and transfusion reactions.
Evaluate blood bank laboratory test results.
Evaluate additional testing required for certain laboratory results of a patient.
Correlate test results with the patient’s condition.

Exam 1 Online 90′	Covers Lecture Units 1 & 2, Labs 1 & 2 Blood Collection Blood/Blood Components Donor History/Physical	Opens Thursday, 2/12/26 0700	Closes Friday, 2/13/26 1900
Exam 2 On Campus 65′	Exam 2 Review opens Monday, February 16, 2026, at 0700 and closes February 23, 2026, at 0830 Covers Lecture Units 3, 4 & 5 (no Labs) Immunology/Complement Principles of Sero Testing in BB Genetics	Mon, 2/23/26 EVC – 0830 Room 8310	Mon, 2/23/26 RRC – 1530
Exam 3 Online 90′	A review will be online from Monday, 3/2, 0700 to Friday, 3/6, 1900. Students must make an 80 or better on this review to open the exam. Covers Lecture Units 6 & 7, Labs 3 & 5 ABO/H Blood Groups Rh Blood Group System ABO/D Typing Lab Rh Phenotyping Lab	Opens Thursday, 3/5/2026 0700	Closes Friday, 3/6/2026, 1900
Exam 4 On Campus 75′ Two Part Exam 60′	Clinical II – Dry Competency Selection of Controls for Antigen Typing ONLINE REQUIRED A review will be online from Wednesday, 4/1/2026, 0700 to Monday, 4/6/2026, 1900. Students must make an 80 or better on this review to open the exam. Covers Lecture Units 8, 9 & 10, Labs 4, 6 & 7 Pretransfusion Testing Other Blood Group Systems ID Unexpected Antibodies Type/Screen Lab Crossmatch Lab ID of Unexpected Abs Exam 4 Part 2 will be open from Monday, 4/6/2026, 0700 to 4/8/2026, 1900.	Opens Monday 4/13/2026 @ 0700 Monday, 4/6/2026, EVC-0830 Room 8310	Closes Sunday 4/19/2026 @ 2359 Monday, 4/6/2026, RRC-1530
Exam 5 Online 75′ Two Part Exam 60′	Exam Review opens 4/27/2026.0700 to 5/1/2026, @ 1900. Covers Lecture Units 11, Labs 8 & 10 Neonatal/Obstetrical Transfusion Practice DAT Lab Rh Immune Globulin Lab Exam 5, Part 2 online opens 4/30/2026 @ 0700 to 5/1/2026 @ 1900	Part One Opens Thursday, 4/30/2026 @ 0700	Part One Closes Friday, 5/1/2026 @ 1900 (7:00pm)

Comprehensive Blood Bank Final – May 11, 2026

EVC – 9:00am to 11:00am
Room 8310
RRC – 3:30pm to 5:30pm
Room 3121
On Campus – two hours

Schedule

Admission tickets and prelab quizzes are due by 8:30 a.m. of the class day.

1/26/2026

Laboratory 1/28/2026	No onsite laboratory this week Lab 1: Donor History Lab 2: Donor Physical Blood Center Tour Quiz – Blackboard under assignments These are due Friday, January 30, 2026
Textbook- bring to class	Chapter 1 – review of safety Chapter 13 and 14
Lecture	*Review of Syllabus* Unit 1: Blood Collection \| Objectives \| Notes Part 1 \| Part 2
Assignments	Laboratory study questions Due 1/30/2026 @ 2359 Laboratory 2 Case Study Due Due 1/30/2026 @ 2359 Prelab 1: Donor Interview and Physical Due 2/2/2026 @ 0830 Prelab 2 – ABO/D Typing Due 2/2/2026 @ 0830 Admission Ticket 1: Blood Collection Due 2/2/2026 @ 0830 Admission Ticket 2 Blood and Blood Components Due 2/2/2026 @ 0830 Admission Ticket 3 – Immunology Testing Due 2/9/2026 @ 0830

2/2/2026

Laboratory	Lab 3: ABO and D Typing
Textbook	Chapter 2, 3, 15
Lecture	Unit 2: Blood and Blood Components \| Objectives \| Notes Unit 3: Immunology and Complement Objectives \| Notes Part 1 \| Part 2 Unit 4: Principles of Serological Testing in Immunohematology Objectives \| Notes
Assignments	Laboratory Exercise Due 2/2/2026 @ 2359 Laboratory Study Questions Due 2/6/2026 @ 2359

2/9/2026

Laboratory	Lab 3: ABO and D Typing (repeat) Print two Type/Screen Report Forms for class
Textbook	Chapters 3
Lecture	See exam schedule
Assignments	Prelab 3 – Type and Screen Due 2/16/2026 @ 0830 Admission Ticket 4: Genetics and ABO/H Due 2/16/2026 @ 0830

2/16/2026

Laboratory	Lab 4: Type and Screen Print one Type/Screen Report Form for class
Textbook	Chapters 4 and 5
Lecture	Unit 5 Genetics \| Objectives \| Notes Unit 6 ABO and H Blood Groups Part One \| Objectives \| Notes Unit 6 ABO and H Blood Groups Part Two \| Notes Practice ABO Discrepancies
Assignments	Laboratory Exercise Due 2/16/2026 @ 2359 Laboratory Study Questions Due 2/20/2026 @ 2359 Prelab 4 – Rh phenotyping and review of ABO/D Due 2/23/2026 @ 0830 Admission Ticket 5 – Rh and Compatibility Due 2/23/2026 @ 0830

2/23/2026

Laboratory	Lab 5: Rh Phenotyping \| Rh Phenotyping Results Form
Textbook	Chapters 6
Lecture	Unit 7: Rh Blood Group System \| Objectives \| Notes Part One Part 2
Assignments	Laboratory Exercise Due 2/23/2026 @ 2359 Laboratory Study Questions Due 2/27/2026 @ 2359 Prelab 5 – Crossmatch/Automation Due 3/2/2026 @ 0830 Admission Ticket 6 – Pretransfusion Compatibility Due 3/2/2026 @ 0830

3/2/2026

Laboratory	REPEAT T/S x 2 Please bring two Type/Screen Report Forms
Textbook	Chapter 9 and 10
Lecture	Unit 8 – Pretransfusion Compatibility Testing Objectives \| Notes Part 1 \| Part 2 \| Part 3
Assignments	See exam information regarding the exam review (Must be taken before exam) Laboratory Exercise ONLY Due 3/2/2026 @ 2359 Prelab 6 – Review of Crossmatch and Discrepancies Due 3/9/2026 @ 0830 Admission Ticket 7 – Automation in BB Due 3/9/2026 @ 0830

3/9/2026

Laboratory	Lab 6: Crossmatch \| Type/Screen Report Form
Textbook	Chapter 9 and 10
Lecture	Unit 8 – Pretransfusion Compatibility Testing Objectives \| Notes Part 1 \| Part 2 \| Part 3
Assignments	Laboratory exercise Due 3/9/2026 @ 2359 Laboratory Study Questions Due 3/13/2026 @ 2359 Admission Ticket 8 – Other Blood Groups Due 3/23/2026 @ 0830

Spring Break 3/16/2026 to 3/20/2026 Enjoy!

3/23/2026

Laboratory	Print one Type/Screen Report Form for practice for today. You will perform the following: Type and Crossmatch for two units
Textbook	Chapter 7 and 8
Lecture	Unit 9: Other Blood Group Systems continued \| Objectives \| Notes Part 1 \| Part 2 Antibody Information Chart (upload under Assignments). Due 4/3/2026 @ 2359
Assignments	Laboratory exercise ONLY Due 3/23/2026 @ 2359 No study questions due on Friday Admission Ticket 9 – Identification of Unexpected Antibodies Due 3/30/2026 @ 0830

3/30/2026

Laboratory	Lab 7: Identification of Unexpected Antibodies Panels for SQ 7 Tutorial: Selecting Positive and Negative Controls for Testing Reagent Antiserum in the Blood Bank Print one Type/Screen Report Form for practice for today. You will perform the following: Type and Crossmatch for two units
Textbook	Chapter 8
Lecture	Unit 10: Identification of Unexpected Antibodies \| Objectives \| Notes
Assignments	Laboratory exercise Due 3/30/2026 @ 2359 Laboratory study questions Due 4/4/2026 @ 359 Prelab 7 Panel Studies Due 4/6/2026 @ 0830 Admission Ticket 10 Neonatal/OB Part 1 Due 4/6/2026 @ 0830

4/6/2026

Laboratory	Three panels – work on today in lab and review with instructor – to be graded before leaving class Bring the following pages with you to class today: Panel Studies for Discussion
Textbook	Chapter 12
Lecture	Unit 11: Neonatal and Obstetrical Transfusion Practice Objectives \| Notes Part 1 \| Part 2 \| Part 3
Assignments	Laboratory Exercise (the three panels) Due 4/6/2026 @ 2359 Admission Ticket 11 Neonatal/OB Part 2 and 3 Due 4/13/2026 @ 0830

4/13/2026

Laboratory	WET Laboratory Practical 1. You will perform the following procedures: Type and crossmatch for two units An ABO/D on an ER patient Print two Type/Screen Report Forms for the practical.
Textbook	Chapter 12
Lecture	Unit 11: Neonatal and Obstetrical Transfusion Practice (continued)
Assignments	Prelab 8 DAT Due 4/20/2026 @ 0830 Prelab 9 Compilation of Prelabs 1-9; This exercise is optional/ not graded Prelab 10 Rh Immune Globulin Workup Due 4/20/2026 @ 0830 Admission Ticket 12 – Adverse Complications of Transfusions Due 4/20/2026 @ 0830 Practical will be collected at the end of the lab.

4/20/2026

Laboratory	Lab 8: Direct Antiglobulin Test (DAT) Do not download the following documents in Google docs because the format will not be correct. Thank you. DAT laboratory result form Lab 9: Rh Immune Globulin Workup Rh Immune Globulin Cord Blood Result Form Fetal Screen Form
Textbook	Chapter 11 DAT versus IAT (short animation)
Lecture	Unit 12: Adverse Complications of Blood Transfusion \| Objectives \| Notes Unit 13: Investigation of the Positive DAT and Immune Hemolysis \| Objectives \| Notes
Assignments	Laboratory Exercise Due 4/20/2026 @ 2359 Laboratory Study Questions for DAT (lab 8) Due 4/24/2026 @ 2359 Laboratory Study Questions for RhIg (lab 9) Due 4/24/2026 @ 2359 Admission Ticket 13 Organ Transplantation and Quality Assurance Due 4/27/2026 @ 0830 Prelab 11 Delayed Transfusion Reaction Workup Due 4/27/2026 @ 0830 Prelab 12 Pulling it all together Due 4/27/2026 @ 0830 Prelab compilation of Prelabs 7-11. This exercise is optional/not graded

4/27/2026

Laboratory	Clinical Panel Competency (Paper) in laboratory Lab 10: Delayed Transfusion Reaction Perform an elution panel
Textbook	Chapter 1 and 11
Lecture	Unit 14: Hemotherapy and Organ Transplantation Objectives \| Notes Unit 15: Quality Assurance in the Blood Bank Objectives \| Notes
Assignments	Laboratory Exercise Due 4/27/2026 @ 2359 Laboratory Study Questions Due 5/1/2026 @ 2359

5/4/2026

Laboratory	WET Practical Laboratory Instructor will provide paperwork Clinical II – Repeat Dry Panel Competency or N/A
Textbook
Lecture	Review for final
Assignments	Practical paperwork due upon completion Complete Immunohematology Student Course Evaluation Your feedback matters! Evaluation period closes on 5/11/2026.

5/11/2026

Laboratory	N/A
Textbook	N/A
Lecture	N/A
Final	See Exam Schedule

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