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MLAB 2431: Immunohematology

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MLAB 2431: Immunohematology

  • Dates: Jan. 16 – May 12, 2024
  • Length of Course: 16 Weeks
  • Classroom Hours: 48 (hybrid)
  • Laboratory Hours: 64

Immunohematology is a specialized branch of laboratory medicine which involves the study of blood group antigens and antibodies. The processes of quality testing include quality control, basic laboratory techniques and safety. It involves the study of the principles, procedures, clinical significance and practice of a wide variety of procedures including: donor selection, component preparation and use, and techniques used to detect antigen/antibody reactions which may adversely affect a patient receiving a transfusion. The topics to be covered include: donor screening, preparation of components, antigens and antibodies of the ABO, Rh and other blood group systems, pretransfusion testing procedures, hemolytic disease of the fetus and newborn, neonatal and obstetrical transfusion practice, autoimmune hemolytic anemias and adverse affects of transfusion.

Course Objectives

  1. Apply the principles of safety, quality assurance, and quality control in immunohematology.
  2. Describe the blood collection process.
  3. State the preparation method, use, storage requirements, and expiration of each blood component.
  4. Evaluate specimen acceptability.
  5. State the principle of each testing procedure performed in Immunohematology.
  6. State the characteristics of the ABO, Rh, and other blood group systems.
  7. List the methods used to identify the most commonly encountered blood group antibodies.
  8. Describe the three types of hemolytic disease of the fetus and newborn (HDFN).
  9. Describe the testing, antibody specificity, and treatment for HDFN.
  10. List the adverse complications of blood transfusion.
  11. State the methods for evaluating a positive direct antiglobulin test.
  12. State the types of immune hemolytic anemias including results of serologic testing and compatibility testing which must be performed.
  13. State the requirements for performing compatibility testing.
  14. Describe the quality control performed in Immunohematology.
  15. Explain the next steps when the quality controls are out of range in Immunohematology.
  16. Describe the immune process as it relates to Immunohematology.
  17. Describe the donor selection process and accurately determine donor eligibility when given results of donor screening tests.
  18. Describe the preparation and the appropriate use of blood components by determining the component needed based on laboratory data.
  19. Describe the characteristics of the antigens and antibodies of the ABO, Rh, and other blood group systems, applying the knowledge to sample testing and case study materials.
  20. Perform blood bank testing in the resolution of antibody problems, HDFN, and transfusion reactions.
  21. Evaluate blood bank laboratory test results.
  22. Evaluate additional testing required for certain laboratory results of a patient.
  23. Correlate test results with the patient’s condition.

Syllabus

Review the video on the MLAB 2431 Syllabus, sign the SOU, and email to the instructor.

Textbook

Howard, Paula R., Basic and Applied Concepts of Blood Banking and Transfusion Practices, Fifth Edition, 2020, Mosby. ISBN: 978-0323697392

Exams

NOTE: Throughout the semester, exams are on different days of the week. Please look closely at the dates the exams are scheduled. Thank you.

Exam 1 On Campus

Covers Lecture Units 1 & 2, Labs 1 & 2

Blood Collection
Blood/Blood Components
Donor History/Physical

Monday, 2/5/24

EVC-8:30am Room 9317

Monday, 2/5/24

RRC-3:30pm
Exam 2 In-house 

Covers Lecture Units 3, 4 & 5 (no Labs)
Immunology/Complement
Principles of Sero Testing in BB
Genetics

 Mon, 2/19/24
EVC – 8:30am
Room 9317		 Mon, 2/19/24
RRC – 3:30pm
Exam 3 Online

A review will be online from Monday, 2/26, 8:30am to Friday, 3/1, 11:59pm. Students must make an 80 or better on this review to open the exam.

Covers Lecture Units 6 & 7, Labs 3 & 5
ABO/H Blood Groups
Rh Blood Group System
ABO/D Typing Lab
Rh Phenotyping Lab

 

 Opens Thursday,
2/29/2024
7:00 am		 Closes
Friday,
3/1/2024,
7:00 pm

 

 

 

 

 

 

Exam 4 On Campus

Two Part Exam
  • Clinical II – Dry Competency
    Selection of Controls for Antigen Typing ONLINE:
    Opens 4/8 @ 0800
    Closes 4/11 @ 2359 REQUIRED

 

A review will be online from Wednesday, 4/10/2024, 0830 to Monday, 4/15/2024, 0830. Students must make an 80 or better on this review to open the exam.

Covers Lecture Units 8, 9 & 10, Labs 4, 6 & 7

Pretransfusion Testing
Other Blood Group Systems
ID Unexpected Antibodies
Type/Screen Lab
Crossmatch Lab
ID of Unexpected Abs

Exam 4 Part 2 will be open from Monday, 4/15/2024, 0700 to 4/17/2024, 1900. 

 

 

Opens Monday
4/8 @ 0800

 

 

 

Monday,  4/15/2024,
EVC-8:30am

Room 9317

 

 

 

Closes Thursday
4/11 @ 2359

 

 

 

Monday,  4/15/2024,
RRC-3:30pm

 

Exam 5

Two Part Exam

Exam Review opens 4/16/2024 to 4/22/2024, @ 1500.

Covers Lecture Units 11, Labs 8 & 10

Neonatal/Obstetrical Transfusion Practice

DAT Lab
Rh Immune Globulin Lab

Exam 5, Part 2 online opens 4/24/2024 @ 0700 to 4/25/2024 @ 1900 

EVC

Room 9317 8:30am

RRC 3:30pm

  

Exam 6 online

Open book

Two Part Exam

Exam 6 Review opens Tuesday, April 30, 2024, at 7:00am and closes May 3, at 7:00pm

Exam Part 1 and Part 2 Covers Lecture Units 12 & 13, Lab 11

Adverse Complications
Investigation of the Positive DAT and Immune Hemolysis

Delayed Transfusion Rxn Lab

Opens Thursday,  5/2/2024,
7:00 am

 

 Closes
Friday, 5/3/2024,
7:00 pm

Comprehensive Blood Bank Final – May 6, 2024

EVC – 9:00am to 11:00am 
RRC – 3:30pm to 5:30pm
This is a tentative date for final – On Campus

Schedule

Admission tickets and prelab quizzes are due by 8:30 a.m. of the class day.

1/22/2024

Laboratory

1/22/2024
Textbook Chapter 13

Lecture
Assignments
  • Prelab 1: Donor Interview and Physical
    Due 1/29/2024 @ 0830
  • Admission Ticket 1: Blood Collection
    Due 1/29/2024 @ 0830
  • Prelab 2 – ABO/D Typing
    Due 1/29/2024 @ 0830
  • Admission Ticket 2
    Blood and Blood Components
    Due 1/29/2024 @ 0830
  • Laboratory study questions
    Due 1/26/2024 @ 2359

1/29/2024

Laboratory
Textbook Chapter 14

Lecture

 
Assignments
  • Laboratory Exercise
    Due 1/29/2024 @ 2359
  • Laboratory Study Questions
    Due 2/2/2024 @ 2359
  • Admission Ticket 3 – Immunology Testing
    Due 2/5/2024 @ 0830

2/5/2024

Laboratory
Textbook Chapters 2 and 3

Lecture

 
Assignments
  • Laboratory exercise ONLY
    Due 2/5/2024 @ 2359
  • Prelab 3 – Type and Screen Due 2/12/2024 @ 0830
  • Admission Ticket 4: Genetics and ABO/H
    Due 2/12/2024 @ 0830

2/12/2024

Laboratory
Textbook Chapters 4 and 5
Lecture
Assignments
  • Laboratory Exercise
    Due 2/12/2024 @ 2359
  • Laboratory Study Questions
    Due 2/16/2024 @ 2359
  • Prelab 4 – Rh phenotyping and review of ABO/D
    Due 2/19/2024 @ 0830
  • Admission Ticket 5 – Rh and Compatibility
    Due 2/19/2024 @ 0830

2/19/2024

Laboratory
Textbook Chapters 6

Lecture

 
Assignments
  • Laboratory Exercise 
    Due 2/19/2024 @ 2359
  • Laboratory Study Questions
    Due 2/23/2024 @ 2359
  • Prelab 5 – Crossmatch/Automation
    Due 2/26/2024 @ 0830
  • Admission Ticket 6 – Pretransfusion Compatibility
    Due 2/26/2024 @ 0830

2/26/2024

Laboratory
Textbook Chapter 8, 9, and 10
Lecture
Assignments
  • See exam information regarding the exam review (Must be taken before exam)
  • Laboratory Exercise
    Due 2/26/2024 @ 2359
  • Laboratory Study Questions
    Due 3/1/2024 @ 2359
  • Prelab 6 – Review of Crossmatch and Discrepancies Due 3/4/2024 @ 0830

3/4/2024

Laboratory
Textbook Chapter 7, 8, 9, and 10

Lecture

 
Assignments
  • Laboratory exercise ONLY
    Due 3/4/2024 @ 2359
  • Admission Ticket 7 – Automation
    Other Blood Groups
    Due 3/25/2024 @ 0830

Spring Break 3/11/2024 to 3/15/2024 Enjoy!

3/18/2024

Laboratory
  • Print two Type/Screen Report Forms for practice for today. You will perform the following:
    1. Type and Screen
    2. Type and Crossmatch for two units
Textbook Chapter 7

Lecture

 
Assignments
  • No study questions due on Friday
  • Laboratory exercise ONLY Due 3/18/2024 @ 2359
  • Admission Ticket 9 Part 1 – Identification of Unexpected Antibodies Due 3/25/2024 @ 0830

3/25/2024

Laboratory
Textbook Chapter 8

Lecture

 
Assignments
  • Laboratory practical will be collected at the end of the lab period.
  • Prelab 7  Panel Studies |
    Due 4/1/2024 @ 0830
  • Admission Ticket 10 Neonatal/OB Part 1
    Due 4/1/2024 @ 0830

4/1/2024

Laboratory
Textbook Chapter 12

Lecture

 
Assignments
  • Laboratory Exercise 
    Due 4/1/2024 @ 2359
  • Laboratory Study Questions
    Due 4/5/2024 @ 2359
  • Admission Ticket 11 Neonatal/OB Part 2 and 3
    Due 4/8/2024 @ 0830
  • Prelab 9 DAT Compilation of Prelabs 1-9; This exercise is optional/ not graded

4/8/2024

Laboratory
  • Clinical II – Dry Competency
    Selection of Controls for Antigen Typing ONLINE:
    Opens 4/8 @ 0800
    Closes 4/11 @ 2359 REQUIRED
Textbook Chapter 12

Lecture

 
  • Unit 11: Neonatal and Obstetrical Transfusion Practice (continued) This is a Zoom meeting. 
  • EVC @ 10:am
  • RRC @ 4:00pm
Assignments
  • (For Clinical II – Three panels – work on today in class and review with instructor – to be graded before leaving class)
  • Prelab 8 DAT Due 4/15/2024 @ 0830
  • Prelab 10 Rh Immune Globulin Workup
    Due 4/15/2024 @ 0830
  • Admission Ticket 12 – Adverse Complications of Transfusions 
    Due 4/22/2024 @ 0830

4/15/2024

 
Textbook Chapter 11

Lecture

 
  • Unit 12: Adverse Complications of Blood Transfusion | Objectives | Notes
  • Unit 13: Investigation of the Positive DAT and Immune Hemolysis | Objectives | Notes
Assignments
  • Laboratory Exercise 
    Due 4/15/2024 @ 2359
  • Laboratory Study Questions
    Due 4/19/2024 @ 2359
  • Admission Ticket 13  Organ Transplantation and Quality Assurance Due 4/22/2024 @ 0830
  • Prelab compilation of Prelabs 7-11. This exercise is optional/not graded
  • Prelab 11 Delayed Transfusion Reaction Workup
    Due 4/22/2024 @ 0830
  • Prelab 12 Pulling it all together
    Due 4/22/2024 @ 0830

4/22/2024

Laboratory
Textbook Chapter 11

Lecture

 
Assignments
  • Laboratory Exercise 
    Due 4/22/2024 @ 2359
  • Laboratory Study Questions
    Due 4/26/2024 @ 2359

4/29/2024

Laboratory
  • WET Practical Laboratory
    Instructor will provide paperwork
  • Clinical II – Repeat Dry Panel Competency or N/A
Textbook Chapter 16

Lecture

 
  • Review for final
Assignments
  • Practical paperwork due upon completion

5/6/2024

Laboratory
 N/A
Textbook N/A
Lecture
 N/A
Final See Exam Schedule

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