MLAB 1415: Hematology

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MLAB 1415: Hematology

- Dates: Aug. 25 – Nov. 2, 2025
- Length of Course: 10 Weeks

Total Contact Hours: 128

The study of blood cells in normal and abnormal conditions. Instructions in the theory and practical application of hematology procedures, including quality control, quality assurance, safety, manual and/or automated methods as well as blood cell maturation sequences, and normal and abnormal morphology with associated diseases.

Course Objectives

By the end of this course the student should be able to:

Apply principles of safety, quality assurance, and quality control in hematology.
Determine suitability of hematology specimens and dispose of them in appropriate biohazard containers.
Compare and contrast hematology values under normal and abnormal conditions.
Evaluate normal and abnormal cell morphology with associated diseases.
Demonstrate an understanding of the cell components of human blood and characteristics, functions, and abnormalities and disease states of each.
Demonstrate proficiency in skills necessary to perform blood cell counts, and evaluations of blood elements within stated limits of accuracy.
Demonstrate compliance with OSHA safety regulations for blood-borne pathogens.
Identify principles and procedures of hematology tests to include sources of error and clinical significance of results.

Syllabus

Please print the MLAB 1415 course syllabus and bring it to class.

Textbook

Keohane, E. M., Butina, M., Mirza, K. M., & Walenga, J. M. (2025). Rodak’s Hematology (7th ed.). Elsevier Health Sciences, ISBN 978-0-323-93650-7
Carr, Jacqueline H., Clinical Hematology Atlas, Sixth Edition, Elsevier, ISBN 978-0-323-711920

Exams

Exam 1On-Campus	Covers: Ch. 1 (Introduction to Hematology), Ch. 4 (Cell Structure & Function), Ch. 5 (Hematopoiesis), Ch. 6 (RBC Production/Destruction), Ch. 7 (RBC Metabolism & Membrane Structure & Function), Ch. 8 (Hemoglobin), Ch. 10 (Leukocytes), Ch. 11 (Platelets), Ch. 15 (Bone Marrow Exam) No labs.	EVC: WednesdaySept. 10, 20258:30-9:30 amRoom 9209	RRC: Wednesday Sept. 10, 20253:30-4:30 pmRoom 3121.00
Exam 2On-Campus	Covers Chapters 8, 16, 17, 18,19 Ch. 9 (Iron), Ch. 16 (Anemias), Ch. 17 (Disorders of Iron Kinetics & Heme Metabolism), Ch.18 (Macrocytic Anemia), Ch. 19 (Bone Marrow Failure) No labs.	EVC: WednesdaySept. 24, 20258:30-9:30 amRoom 9209	RRC: Wednesday Sept. 24, 20253:30-4:30 pmRoom 3121.00
Exam 3On- Campus	Covers: Ch. 20 (Introduction to Hemolytic Anemias), Ch. 21 (Intrinsic Defects Affecting RBCs), Ch. 22 (Extrinsic Defects Affecting RBCs- Nonimmune), Ch. 23 (Extrinsic Defects Affecting RBCs- Immune) No labs.	EVC: WednesdayOctober 8, 20258:30-9:30amRoom 8301	RRC: WednesdayOctober 8, 20253:30-4:30 pmRoom 3121.00
Exam 4:On-Campus	Covers Chapters 24, 25, 26 Ch. 24 (Hemoglobinopathies) Ch. 25 (Thalassemias) Ch. 26 (Non-Malignant WBC Disorders) No labs.	EVC: WednesdayOct. 15, 20258:30-9:30 amRoom 9209	RRC: WednesdayOct. 15 2025 3:30-4:30 pmRoom 3121.00
Exam 5:Remote	Covers: Introduction to Hematopoietic Neoplasms Ch. 27 (Introduction to Hematologic Malignancies), Ch. 31 (Acute Leukemias), Ch. 32 (Myeloproliferative Disorders), Ch. 33 (Myelodysplastic Syndromes), Ch. 34 (Mature Lymphoid Neoplasms) No labs.	Opens: Friday, Oct. 24, 2025 at 7:00 am	Closes: Saturday, Oct. 25, 2025 at 7:00 pm
PRACTICAL EXAM:On-Campus	Covers all labs	EVC: Wednesday Oct. 29, 20258:30-9:30 am Room 9209	RRC: WednesdayOct. 29, 2025 3:30-4:30 p.mRoom 3121.00
FINAL EXAM:On-Campus	Covers all course material.	EVC: Thursday Oct. 30, 20258:30-10:30 amRoom 8301	RRC: Thursday Oct. 30, 20253:30- 5:30 pmRoom 3121.00

Schedule

Admission tickets (ATs) and Pre-labs (PLs) are due by 8:30 a.m.

Week of 8/25/2025

Topic	N/A
Textbook	N/A
Laboratory	N/A
Assignment	PL: Microhematocrit. Pre-lab is found in Bb under assignments tab. Due 8/27/25 PL: ESR. Pre-lab is found in Bb under assignments tab. Due 8/27/25

Wednesday 8/27/25

Laboratory Topic	Syllabus Q & A Microhematocrit Erythrocyte Sedimentation Rate
Textbook	Ch. 1, pp. 1-7 Introduction to Hematology Ch. 4, pp. 43-55 Cell Structure & Function Hematology Atlas- Table 2-1, page 16 Ch. 5, pp. 59-74 Hematopoiesis
Lecture Topics	Introduction to Hematology \| Objectives \| Notes Cellular Structure & Function \| Objectives \| Notes Hematopoiesis \| Objectives \| Notes
Assignment	PL: Blood Smear Preparation and Staining. Pre-lab is found in Bb under assignments tab. Due 8/28/25 Read pages 2-7 in Hematology Atlas Admission Ticket: Hematopoietic Organs and Bone Marrow. Found in Bb under assignments tab. Due 8/28/25 Cell Components and Function. Submit to Dropbox in Bb. Due 8/31/25

Thursday 8/28/25

Laboratory Topic	Blood Smear Preparation and Staining
Textbook	Ch. 15, pp. 244-260 Bone Marrow Exam
Lecture Topics	Hematopoietic Organs \| Objectives \| Notes Bone Marrow \| Objectives \| Notes
Assignment	Marrow Growth in Fetus and Adult. Submit to Dropbox in Bb. Due 8/31/25

Wednesday 9/3/25

Laboratory Topic	Atlas Review: Basic cells Hematek Stainer Blood Smear Lab con’t
Textbook	Ch. 10, pp. 139-154 Leukocytes Ch. 11, pp. 159-174 Platelets
Lecture Topics	Leukocytes \| Objectives \| Notes Part 1 \| Part 2 \| Part 3 Platelets \| Objectives \| Notes
Assignment	PL: Reticulocyte: Pre-lab is found in Bb under assignments tab. Due 9/4/25 Myelocytic Series drawings. Due 9/7/25

Thursday 9/4/25

Laboratory Topic	Reticulocyte Count
Textbook	Ch. 6, pp. 78-91 RBC Production/Destruction Ch. 7, pp. 95-105 RBC Metabolism & Membrane Structure & Function Ch. 8, pp. 109-120 Hemoglobin Metabolism
Lecture Topics	Erythrocytes \| Objectives \| Notes Part 1 \| Part 2 Hemoglobin \| Objectives \| Notes
Assignment	Admission Ticket: Anemia. Found in Bb under assignments tab. Due 9/10/25 PL: Electrical Impedance & Colorimetric Measurements: Pre-lab is found in Bb under assignments tab. Due 9/10/25 Hemoglobin Assignment. Due 9/7/25 RBC Metabolic Pathways Assignment: Submit to Dropbox: Due 9/7/2025

Wednesday 9/10/25

Laboratory Topic	Morphology Checklist Electrical Impedance and Colorimetric Measurements
Textbook	Ch. 16, pp. 262-272 Anemias- Introduction
Lecture Topics	Anemia \| Objectives \| Notes Part 1 \| Part 2 \| Part 3 \| Part 4
Assignment	Admission Ticket: Hypochromic Anemias. Found in Bb under assignments tab. Due 9/11/25 Hematology Math. Submit to Dropbox in Bb. Due 9/14/25

Thursday 9/11/25

Laboratory Topics	Optical Light Scatter and Flow Cytometry Flow tutorial Sysmex XN- 430 Overview Use information in this presentation for the Hematology Automation Report. Upload Automation Report to Clinical I course. Additional information found in the Clinical I course, under Portfolio. Due by Sunday 9/26/2025, 11: 59 pm RBC Morphology Checklist, if applicable
Textbook	Ch. 9, pp. 122-135 Iron Kinetics Ch. 17, pp. 275-290 Disorders of Iron Kinetics & Heme Metabolism
Lecture Topics	Review Exam 1, as needed Iron Metabolism and Hypochromic Anemias \| Objectives \| Notes
Assignment	PL: RBC Morphology on Peripheral Smear. Pre-lab is found in Bb under assignments tab. Due 9/17/25 Admission Ticket: Macrocytic and Aplastic Anemias. Found in Bb under assignments tab. Due 9/17/25

Wednesday 9/17/25

Laboratory Topics	RBC Morphology on a Peripheral Blood Smear
Textbook	Ch.18, pp. 296-309 Macrocytic Anemia Ch. 19, pp. 313-325 Bone Marrow Failure
Lecture Topics	Review Hematology Math as needed Macrocytic Anemias \| Objectives \| Notes Hypoproliferative Anemias \| Objectives \| Notes
Assignment	PL: RBC Morphology & Auto CBC Correlation. Pre-lab is found in Bb under assignments tab. Due 9/18/25 Case study #1: Found in Bb under assignments, in Hematology case studies. Due 9/24/25 @ 11:55 pm

Thursday 9/18/25

Laboratory Topics	RBC Morphology and Automated CBC Correlation
Textbook	Ch. 20, pp. 330-348 Introduction to Hemolytic Anemias Ch. 21, pp. 352-374 Intrinsic Defects Affecting RBCs
Lecture Topics	Introduction to Hemolytic Anemias \| Objectives \| Notes Hemolytic Anemias: Membrane Defects \| Objectives \| Notes Part 1 \| Part 2
Assignment	Watch video on Intravascular Hemolysis (~10 minutes long) Watch video on Extravascular Hemolysis (~10 minutes long) PL: WBC & PLT estimates/inclusions: Pre-lab is found in Bb under assignments tab. Due 9/24/25 Admission Ticket: Hemolytic Anemias/Enzyme Deficiency: Found in Bb under assignments tab. Due 9/24/25

Wednesday 9/24/25

Laboratory Topics	WBC and Platelet Estimates and Morphology
Textbook	NA
Lecture Topics	Hemolytic Anemias: Enzyme Deficiencies \| Objectives \| Notes
Assignment	N/A

Thursday 9/25/25

Laboratory Topics	Atlas Review: Normal WBCs Sysmex Activity
Textbook	Ch. 23, pp. 392-405 Extrinsic Defects Affecting RBCs- Immune
Lecture Topics	Review Exam 2, as needed Hemolytic Anemias: Immune Anemias \| Objectives \| Notes
Assignment	PL: Counting to 100: Pre-lab is found in Bb under assignments tab. Due 10/1/25

Wednesday 10/1/25

Laboratory Topics	Counting to 100
Textbook	Ch. 22, pp. 379-389 Extrinsic Defects Affecting RBCs- Nonimmune
Lecture Topics	Hemolytic Anemias: Nonimmune Hemolysis \| Objectives \| Notes
Assignment	Admission Ticket: Hemoglobinopathies and Thalassemias. Found in Bb under assignments tab. Due 10/2/25 PL: Manual Differentials. Pre-lab is found in Bb under assignments tab. Due 10/2/25 Watch this video for an Introduction to Thalassemia. Optional: Watch this video illustrating one example of nonimmune hemolytic anemia

Thursday 10/2/25

Laboratory Topics	Manual Differential
Textbook	Ch. 24, pp. 408-435 Hemoglobinopathies Ch. 25, pp. 440-460 Thalassemias
Lecture Topics	The Hemoglobinopathies \| Objectives \| Notes Part 1 \| Part 2 Thalassemia \| Objectives \| Notes
Assignment	Watch this video on Alpha Thalassemia. Watch this video on Beta Thalassemia. Admission Ticket: Granulocyte, Monocyte, and Nonmalignant Lymph Disorders. Found in Bb under assignments tab. Due 10/8/25 Case Study #2: Found in Bb, under assignments, in Hematology case studies. Due 10/9/25 @ 11:55 pm

Wednesday 10/8/25

Laboratory Topics	Specimen through Differential and Establishing Reference Ranges Handling Abnormal Automated CBC Results Critical Thinking Exercise: Spurious Results
Textbook	Ch. 26, pp. 464-485 Non-Malignant WBC Disorders
Lecture Topics	Nonmalignant Granulocyte and Monocyte Disorders \| Objectives \| Notes Nonmalignant Lymphocyte Disorders \| Objectives \| Notes
Assignment	N/A

Thursday 10/9/25

Laboratory Topics	Atlas Review- Abnormal/Immature Cells Morphology Checklist: Abnormals/Immatures Due 10/15/25
Textbook	Ch. 27, pp. 489-497 Introduction to Hematologic Malignancies
Lecture Topics	Review Exam 3, as needed Introduction to Hematopoietic Neoplasms \| Objectives \| Notes
Assignment	Admission Ticket: Myeloproliferative Disorders. Found in Bb under assignments tab. Due 10/15/25

Wednesday 10/15/25

Laboratory Topics	Morphology Checklist: Abnormals/Immature, if needed
Textbook	Ch. 32, pp. 583-613 Myeloproliferative Disorders Ch. 33, pp. 618-628 Myelodysplastic Syndromes
Lecture Topics	Myeloproliferative Disorders \| Objectives \| Notes Myelodysplastic Syndromes \| Objectives \| Notes
Assignment	Admission Ticket: Acute Lymphocytic Leukemia. Found in Bb under assignments tab. Due 10/16/25 Case Study #3. Found in Bb, under assignments, in Hematology case studies. Due 10/22/25 @ 11:55 pm

Thursday 10/16/25

Laboratory Topic	Manual Differential Report Form – Abnormal Set A
Textbook	Ch. 31, pp. 566-580 Acute Leukemias
Lecture Topic	Review Exam 4, as needed Acute Myeloid Leukemias \| Objectives \| Notes Acute Lymphoblastic Leukemia\| Objectives \| Notes
Assignment	Complete Hematology Student Course Evaluation- found in the Blackboard course Your feedback matters! Evaluation period closes on 10/27/2025.

Wednesday 10/22/25

Laboratory Topic	Manual Differential Report Form – Abnormal Set B
Textbook	Ch. 34, pp. 634-657 Mature Lymphoid Neoplasms
Lecture Topics	Lymphoid Malignancies \| Objectives \| Notes
Assignment	N/A