MLAB 1335: Immunology & Serology

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Current Students

MLAB 1335: Immunology & Serology

Dates: October 16 through December 10, 2023
Length of Course: 8 Weeks
Total Contact Hours: 96

An introduction to the theory and application of basic immunology, including the immune response, principles of antigen-antibody reactions, and the principles of serological procedures.

Course Objectives

By the end of this course, the student should be able to:

Discuss the principles involved in the immune response.
Describe the structure, function, and characteristics of immunoglobulins.
Describe the principles of and perform serological tests.
Evaluate laboratory test outcomes and relate serology tests to the disease or condition associated with each test; and evaluate the suitability of clinical specimens.

Syllabus

Please print the course syllabus and bring it to class.

Textbook (Recommended)

Stevens, C. & Miller, L. (2017). Clinical Immunology and Serology: A Laboratory Perspective, 4th edition. Philadelphia: F. A. Davis.

Exams and Practical

Exam 1 In-house	Unit 1 exam covers Introduction and Historical Concepts Non-Specific Immunity Cytokines and Acute Phase Reactants Specific Immunity Antigens and Antibodies Hypersensitivity Reactions Complement Glassware Serial Dilutions	EVC Monday, 11/6/23 Room 9209 8:30am – 10:00am	RRC Monday, 11/6/23 Room 3121.00 3:30pm – 5:30pm
Exam 2 ONLINE	Unit 2 exam covers the following: Basic Immunologic Procedures Agglutination and Flocculation Competitive and Non-Competitive Binding Assays Molecular Diagnostics	Opens Thursday, 11/16/23, 7:00 am	Closes Friday, 11/17/23, 7:00 pm
Exam 3 ONLINE	Unit 3 exam covers the following: Introduction to Autoimmune Diseases SLE and ANA RA Organ-Specific Autoimmune Diseases Immunodeficiency Diseases including HIV	Opens Thursday, 11/30/23, 7:00 am	Closes Friday, 12/1/23, 7:00 pm
Lab Practical In-house	Covers all laboratory material including glassware, serial dilutions, pregnancy testing, RPR, HIV, CRP, RF, and cold agglutinins.	Monday, 12/4/23, 8:30am Room 9209	Monday, 12/4/23, 3:30 pm Room 3121
Final Exam In-house	Covers all course material.	Tuesday, December 5, 2023, 8:30am Room 9317	Tuesday, December 5, 2023, 3:30 pm Room 3121

Schedule

All Admission Tickets and Prelabs are due on the posted date by 8:30 a.m.

10/16/2023

Lecture	Objectives – These are objectives for ALL of unit one Unit 1, Part 1: Nature of the Immune System – Introduction & Historical Concepts Notes
Textbook	Chapters 1 through 7 and 14 Enhancement Information Understanding Serological Pipettes (YouTube) Serial Dilution Method Protocol Step Wise Explanation (YouTube) Bacterial Serial Dilutions – Antibodies and antigens cannot be visualized, since they are soluble. But by looking at the decreasing number of organisms on the plate as the bacterial culture was diluted, one can get a sense of what is happening in the test tube as a serum sample is diluted. Review Introduction to Immunology Watch The Process of Phagocytosis (YouTube) Watch Natural Killer Cells (YouTube)
Laboratory	Quality Assurance in Serology Laboratory Glassware Objectives and Notes How to Pipette: Lab Survival Skills (YouTube) Serological Pipettes Dilutions From Clinical I – Cell Count Competency Assessment Hemacytometers Cell Count Report Form After competency, complete UA practice for competency repeats
Assignment	Lecture Admission Ticket #1 Due 10/17/2023 Prelab Assessment #1 and #2 Due 10/17/2023

10/17/2023

Lecture	Objectives – These are objectives for ALL of unit one Unit 1, Part 2: Non-Specific Immunity Notes Unit 1, Part 3: Acute Phase Reactants Notes
Textbook	Chapters 1 through 7 and 14 Enhancement Information Understanding Serological Pipettes (YouTube) Serial Dilution Method Protocol Step Wise Explanation (YouTube) Bacterial Serial Dilutions – Antibodies and antigens cannot be visualized, since they are soluble. But by looking at the decreasing number of organisms on the plate as the bacterial culture was diluted, one can get a sense of what is happening in the test tube as a serum sample is diluted. Review Introduction to Immunology Watch The Process of Phagocytosis (YouTube) Watch Natural Killer Cells (YouTube)
Laboratory	Lab: Serial Dilution to Detect Cold Reacting Antibodies Clinical I – Serial Dilution using Automatic Pipettes
Assignment	Lecture Admission Ticket #2 Due 10/24/2023 Prelab Assessment RPR Due 10/24/2023 Choose a case study topic for your presentation. Email professor for approval, then post your topic on the discussion board. Due 11/5/2023 @ 11:59 pm

10/23/2023

Lecture	Objectives – These are objectives for ALL of unit one Unit 1, Part 4: Specific (Acquired) Immunity Notes Unit 1, Part 5: Humoral Immunity Notes
Textbook	Chapters 1 through 7 and 14
Laboratory	Laboratory – Serial Dilution Practice using Serological Pipettes Clinical I -Repeat UA competency, if applicable
Assignment	Post response to “To Be or Not To Be” to the Discussion Board Due October 29, 2023, 11:59 p.m.

10/24/2023

Lecture	Objectives – These are objectives for ALL of unit one Unit 1, Part 6: Hypersensitivity Part A Notes Unit 1, Part 6: Hypersensitivity Part B Notes
Textbook	Chapters 1 through 7 and 14
Laboratory	Urine Pregnancy Test Laboratory Quick Vue hCG Combo Package Insert
Assignment	Prelab Assessment Pregnancy Testing Due 10/30/2023 Admission Ticket #3 Part 7 – Complement Due 10/30/2023

10/30/2023

Lecture	Objectives – These are objectives for ALL of unit one Unit 1, Part 7: Complement Notes
Textbook	Chapters 1 through 7 and 14 Enhancement Information Enzyme Immunoassay (EIA) to Detect Antigens (YouTube) Explore this website Cells Alive
Laboratory	Complement Case Study – Read and answer the questions. Due 11/5/2023 11:59 pm RPR Laboratory exercise
Assignment	Prelab Assessment ABO Blood Typing Due 11/7/2023

10/31/2023

Lecture	Review for Exam One
Textbook	Chapters 1 through 7 and 14
Laboratory	Serial Dilution Practice
Assignment	Lecture Admission Ticket #4 Due 11/7/2023

11/6/2023

Lecture	Exam One – See schedule above Objectives – These are objectives for ALL of unit two Unit 2 Part 1 – Basic Immunoassay Principles 2020
TextbookEnrichment	Chapters 10 and 11 Ouchterlony Method Ouchterlony Examples Ouchterlony Double Diffusion – Titration Great info from Amrita YouTube Video on Ouchterlony Method Overview of ELISA from ThermoFisher Scientific
Laboratory	In Clinical I Serial dilution competency
Assignment	Reminder: Case study presentation outlines are to be uploaded on Tuesday, November 28, 2023, by 2359. Presentations will be completed by each student in class on Tuesday, November 28, 2023.

11/7/2023

Lecture	Objectives – These are objectives for ALL of unit two Unit 2 Part 2 – Agglutination and Flocculation Unit 2 Part 3 – Labeled Immunoassays
TextbookEnrichment	Chapters 10 and 11
Laboratory	ABO Blood Typing Laboratory Exercise
Assignment	Lecture Admission Ticket #5 Due 11/14/2023 Prelab Assessment – Molecular Techniques Due 11/13/2023. Use the lecture material to answer the questions.

11/13/2023

Lecture	Unit Three Objectives Section A Unit 3 Part 1 – Introduction To Autoimmune Diseases
Textbook	Chapters 19, 21, 23, and 24
Laboratory	Discussion of PCR testing Introduction to Molecular Diagnostics
Assignment	Admission Ticket #5 Due 11/14/2023 (reminder/posted last week)

11/14/2023

Leture	Unit Three Objectives Section A Unit 3 Part 2 – SLE and ANA Unit 3 Part 3 – Rheumatoid Arthritis
Textbook	Chapters 19, 21, 23, and 24
Laboratory	HIV Laboratory Exercise HIV Laboratory Report Form Repeat serial dilution competency, if applicable
Assignment	Prelab CRP Due 11/20/2023 Prelab Rheumatoid Factor Due 11/20/2023

11/20/2023

Lecture	Unit Three Objectives – Section B No onsite class today
Textbook	N/A
Laboratory	Laboratory Exercises are due on Tuesday, November 28, 2023, at 11:59 p.m. All of the information required for these exercises are listed here. Please upload into Blackboard upon completion of the exercise and the study questions. C-Reactive Protein Laboratory Exercise and Study Questions C-Reactive Protein Patient and Control Results C-Reactive Protein Package Insert Rheumatoid Factor Laboratory Exercise and Study Questions Rheumatoid Factor Patient and Control Results Rheumatoid Factor Package Insert
Assignment	Admission Ticket # 6 Due 11/27/2023 Admission Ticket # 7 Due 11/27/2023 Prelab Infectious Mono Due 11/27/2023 Prelab Cold Agglutinin Due 11/28/2023

11/21/2023

Lecture	Happy Thanksgiving!
Textbook	N/A
Laboratory	N/A
Assignment	N/A

11/27/2023

Lecture	Unit Three Objectives – Section B Unit 3 – Part 4 – Organ-Specific Autoimmune Diseases Unit 3 – Part 5 – Immunodeficiency Diseases including HIV
Textbook	Chapters 12, 19, 20, 21, 23, and 24
Laboratory	Mononucleosis Testing Laboratory Exercise
Assignment	Admission Ticket #8 Due 11/28/2023 Prelab Cold Agglutinin Due 11/28/2023 (reminder)

11/28/2023

Lecture	Unit 4 Objectives -Syphilis, Lyme disease, and Hepatitis Unit 4 Serological Diagnosis of Infectious Diseases CDC – Interpretation of HBV results in chart form Case study outline to be uploaded today to Blackboard Case Study Presentations TODAY Review for Final Exam
Textbook	N/A
Laboratory	N/A
Assignment	Cold Agglutinin Case Study and Study Questions Due Friday, December 1, 2023 @ 11:59pm

The Week of 12/4/2023

Laboratory Practical	Monday, December 4, 2023 (see exam schedule) This exam covers ALL laboratory activities
Final Exam	Tuesday, December 5, 2023 (see exam schedule)

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MLAB 1335: Immunology & Serology

Current Students

MLAB 1335: Immunology & Serology

Course Objectives

Syllabus

Textbook (Recommended)

Exams and Practical

Schedule

10/16/2023

10/17/2023

10/23/2023

10/24/2023

10/30/2023

10/31/2023

11/6/2023

11/7/2023

11/13/2023

11/14/2023

11/20/2023

11/21/2023

11/27/2023

11/28/2023

The Week of 12/4/2023

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Updates

Medical Laboratory Technology Updates

Phlebotomy Technician Program Applications

Medical Laboratory Technology Program Applications

Attention! All students that have not been accepted into an ACC Health Sciences program…

Courses

Medical Laboratory Technology Courses

MLT Courses

Phlebotomy Courses